The energetics of transmembrane helix insertion into a lipid bilayer.
Free energy profiles for insertion of a hydrophobic transmembrane protein α-helix (M2 from CFTR) into a lipid bilayer have been calculated using coarse-grained molecular dynamics simulations and umbrella sampling to yield potentials of mean force along a reaction path corresponding to translation of...
Main Authors: | Chetwynd, A, Wee, C, Hall, B, Sansom, MS |
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פורמט: | Journal article |
שפה: | English |
יצא לאור: |
2010
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פריטים דומים
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