Building up key segments of N-glycans in the gas phase: intrinsic structural preferences of the alpha(1,3) and alpha(1,6) dimannosides.
The intrinsic conformer specific vibrational spectra of two important subunits of the core pentasaccharide of N-linked glycans, the alpha(1,3) and alpha(1,6) dimannosides, have been recorded in the gas phase. Coupling these measurements with a computational exploration of their conformational landsc...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2006
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| _version_ | 1826287887982788608 |
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| author | Carçabal, P Hünig, I Gamblin, D Liu, B Jockusch, R Kroemer, RT Snoek, L Fairbanks, A Davis, B Simons, J |
| author_facet | Carçabal, P Hünig, I Gamblin, D Liu, B Jockusch, R Kroemer, RT Snoek, L Fairbanks, A Davis, B Simons, J |
| author_sort | Carçabal, P |
| collection | OXFORD |
| description | The intrinsic conformer specific vibrational spectra of two important subunits of the core pentasaccharide of N-linked glycans, the alpha(1,3) and alpha(1,6) dimannosides, have been recorded in the gas phase. Coupling these measurements with a computational exploration of their conformational landscapes has enabled their conformational assignment and has identified characteristic vibrational signatures associated with particular conformational families-including those that do or do not display inter-ring hydrogen bonding across the glycosidic linkage. In addition, the IR spectra of the monosaccharide moieties provide benchmarks, through which the conformational assignments can be refined. This introduces a general concept of modularity and secondary structure in oligosaccharides--essential for the success of similar studies on larger oligosaccharides in the future. |
| first_indexed | 2024-03-07T02:05:25Z |
| format | Journal article |
| id | oxford-uuid:9ed5d048-9ab1-4f7c-a8d4-33bd59b7f3ad |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:05:25Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:9ed5d048-9ab1-4f7c-a8d4-33bd59b7f3ad2022-03-27T00:52:56ZBuilding up key segments of N-glycans in the gas phase: intrinsic structural preferences of the alpha(1,3) and alpha(1,6) dimannosides.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9ed5d048-9ab1-4f7c-a8d4-33bd59b7f3adEnglishSymplectic Elements at Oxford2006Carçabal, PHünig, IGamblin, DLiu, BJockusch, RKroemer, RTSnoek, LFairbanks, ADavis, BSimons, JThe intrinsic conformer specific vibrational spectra of two important subunits of the core pentasaccharide of N-linked glycans, the alpha(1,3) and alpha(1,6) dimannosides, have been recorded in the gas phase. Coupling these measurements with a computational exploration of their conformational landscapes has enabled their conformational assignment and has identified characteristic vibrational signatures associated with particular conformational families-including those that do or do not display inter-ring hydrogen bonding across the glycosidic linkage. In addition, the IR spectra of the monosaccharide moieties provide benchmarks, through which the conformational assignments can be refined. This introduces a general concept of modularity and secondary structure in oligosaccharides--essential for the success of similar studies on larger oligosaccharides in the future. |
| spellingShingle | Carçabal, P Hünig, I Gamblin, D Liu, B Jockusch, R Kroemer, RT Snoek, L Fairbanks, A Davis, B Simons, J Building up key segments of N-glycans in the gas phase: intrinsic structural preferences of the alpha(1,3) and alpha(1,6) dimannosides. |
| title | Building up key segments of N-glycans in the gas phase: intrinsic structural preferences of the alpha(1,3) and alpha(1,6) dimannosides. |
| title_full | Building up key segments of N-glycans in the gas phase: intrinsic structural preferences of the alpha(1,3) and alpha(1,6) dimannosides. |
| title_fullStr | Building up key segments of N-glycans in the gas phase: intrinsic structural preferences of the alpha(1,3) and alpha(1,6) dimannosides. |
| title_full_unstemmed | Building up key segments of N-glycans in the gas phase: intrinsic structural preferences of the alpha(1,3) and alpha(1,6) dimannosides. |
| title_short | Building up key segments of N-glycans in the gas phase: intrinsic structural preferences of the alpha(1,3) and alpha(1,6) dimannosides. |
| title_sort | building up key segments of n glycans in the gas phase intrinsic structural preferences of the alpha 1 3 and alpha 1 6 dimannosides |
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