A novel checkpoint mechanism regulating the G1/S transition.
Ultraviolet irradiation of fission yeast cells in G1 phase induced a delay in chromatin binding of replication initiation factors and, consistently, a transient delay in S-phase entry. The cell cycle delay was totally dependent on the Gcn2 kinase, a sensor of the nutritional status, and was accompan...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797085199829303296 |
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| author | Tvegård, T Soltani, H Skjølberg, H Krohn, M Nilssen, E Kearsey, S Grallert, B Boye, E |
| author_facet | Tvegård, T Soltani, H Skjølberg, H Krohn, M Nilssen, E Kearsey, S Grallert, B Boye, E |
| author_sort | Tvegård, T |
| collection | OXFORD |
| description | Ultraviolet irradiation of fission yeast cells in G1 phase induced a delay in chromatin binding of replication initiation factors and, consistently, a transient delay in S-phase entry. The cell cycle delay was totally dependent on the Gcn2 kinase, a sensor of the nutritional status, and was accompanied by phosphorylation of the translation initiation factor eIF2alpha and by a general depression of translation. However, the G1-specific synthesis of factors required for DNA replication was not reduced by ultraviolet radiation. The cell cycle delay represents a novel checkpoint with a novel mechanism of action that is not activated by ionizing radiation. |
| first_indexed | 2024-03-07T02:05:33Z |
| format | Journal article |
| id | oxford-uuid:9ee2d0f9-fd0c-46b0-b426-9b643f6e8667 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:05:33Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:9ee2d0f9-fd0c-46b0-b426-9b643f6e86672022-03-27T00:53:16ZA novel checkpoint mechanism regulating the G1/S transition.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9ee2d0f9-fd0c-46b0-b426-9b643f6e8667EnglishSymplectic Elements at Oxford2007Tvegård, TSoltani, HSkjølberg, HKrohn, MNilssen, EKearsey, SGrallert, BBoye, EUltraviolet irradiation of fission yeast cells in G1 phase induced a delay in chromatin binding of replication initiation factors and, consistently, a transient delay in S-phase entry. The cell cycle delay was totally dependent on the Gcn2 kinase, a sensor of the nutritional status, and was accompanied by phosphorylation of the translation initiation factor eIF2alpha and by a general depression of translation. However, the G1-specific synthesis of factors required for DNA replication was not reduced by ultraviolet radiation. The cell cycle delay represents a novel checkpoint with a novel mechanism of action that is not activated by ionizing radiation. |
| spellingShingle | Tvegård, T Soltani, H Skjølberg, H Krohn, M Nilssen, E Kearsey, S Grallert, B Boye, E A novel checkpoint mechanism regulating the G1/S transition. |
| title | A novel checkpoint mechanism regulating the G1/S transition. |
| title_full | A novel checkpoint mechanism regulating the G1/S transition. |
| title_fullStr | A novel checkpoint mechanism regulating the G1/S transition. |
| title_full_unstemmed | A novel checkpoint mechanism regulating the G1/S transition. |
| title_short | A novel checkpoint mechanism regulating the G1/S transition. |
| title_sort | novel checkpoint mechanism regulating the g1 s transition |
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