Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.

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Cells respond to DNA double-strand breaks by recruiting factors such as the DNA-damage mediator protein MDC1, the p53-binding protein 1 (53BP1), and the breast cancer susceptibility protein BRCA1 to sites of damaged DNA. Here, we reveal that the ubiquitin ligase RNF8 mediates ubiquitin conjugation a...

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Main Authors: Kolas, N, Chapman, JR, Nakada, S, Ylanko, J, Chahwan, R, Sweeney, F, Panier, S, Mendez, M, Wildenhain, J, Thomson, T, Pelletier, L, Jackson, S, Durocher, D
פורמט: Journal article
שפה:English
יצא לאור: 2007

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