Tryptophan-mediated interactions between tristetraprolin and the CNOT9 subunit are required for CCR4-NOT deadenylase complex recruitment

Tryptophan-mediated interactions between tristetraprolin and the CNOT9 subunit are required for CCR4-NOT deadenylase complex recruitment

The zinc-finger protein tristetraprolin (TTP) binds to AU-rich elements present in the 3' untranslated regions of transcripts that mainly encode proteins of the inflammatory response. TTP-bound mRNAs are targeted for destruction via recruitment of the eight-subunit deadenylase complex 'car...

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Bibliographic Details
Main Authors: Bulbrook, D, Brazier, H, Mahajan, P, Kliszczak, M, Fedorov, O, Marchese, F, Aubareda, A, Chalk, R, Picaud, S, Strain-Damerell, C, Filippakopoulos, P, Gileadi, O, Clark, A, Yue, W, Burgess-Brown, N, Dean, J
Format: Journal article
Language:English
Published: Elsevier 2017

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