Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality

The human brain is a complex, three-dimensional structure. To better recapitulate brain complexity, recent efforts have focused on the development of human-specific midbrain organoids. Human iPSC-derived midbrain organoids consist of differentiated and functional neurons, which contain active synaps...

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Hlavní autoři: Sabate-Soler, S, Nickels, SL, Saraiva, C, Berger, E, Dubonyte, U, Barmpa, K, Lan, YJ, Kouno, T, Jarazo, J, Robertson, G, Sharif, J, Koseki, H, Thome, C, Shin, JW, Cowley, SA, Schwamborn, JC
Médium: Journal article
Jazyk:English
Vydáno: Wiley 2022