Phorbol ester-induced expression and function of the interleukin 2 receptor in human B lymphocytes.
The expression of the interleukin 2 receptor (Tac) on normal B cells and Epstein-Barr virus-transformed lymphoblastoid B cell lines is induced by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The receptor on B cells is indistinguishable from that on T cells by serological and bioch...
| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
1985
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| _version_ | 1826287962485161984 |
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| author | Ando, I Crawford, D Kissonerghis, M Owen, M Beverley, P |
| author_facet | Ando, I Crawford, D Kissonerghis, M Owen, M Beverley, P |
| author_sort | Ando, I |
| collection | OXFORD |
| description | The expression of the interleukin 2 receptor (Tac) on normal B cells and Epstein-Barr virus-transformed lymphoblastoid B cell lines is induced by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The receptor on B cells is indistinguishable from that on T cells by serological and biochemical analysis. It is functionally active so that TPA-induced B cells respond to interleukin 2 by increased DNA synthesis. These results suggest that the expression of Tac is not exclusively restricted to T cells and that interleukin 2 may play a role in B cell differentiation. |
| first_indexed | 2024-03-07T02:06:33Z |
| format | Journal article |
| id | oxford-uuid:9f32fef4-f1f3-4f49-8cff-dcf71cf25c2c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:06:33Z |
| publishDate | 1985 |
| record_format | dspace |
| spelling | oxford-uuid:9f32fef4-f1f3-4f49-8cff-dcf71cf25c2c2022-03-27T00:55:32ZPhorbol ester-induced expression and function of the interleukin 2 receptor in human B lymphocytes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9f32fef4-f1f3-4f49-8cff-dcf71cf25c2cEnglishSymplectic Elements at Oxford1985Ando, ICrawford, DKissonerghis, MOwen, MBeverley, PThe expression of the interleukin 2 receptor (Tac) on normal B cells and Epstein-Barr virus-transformed lymphoblastoid B cell lines is induced by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The receptor on B cells is indistinguishable from that on T cells by serological and biochemical analysis. It is functionally active so that TPA-induced B cells respond to interleukin 2 by increased DNA synthesis. These results suggest that the expression of Tac is not exclusively restricted to T cells and that interleukin 2 may play a role in B cell differentiation. |
| spellingShingle | Ando, I Crawford, D Kissonerghis, M Owen, M Beverley, P Phorbol ester-induced expression and function of the interleukin 2 receptor in human B lymphocytes. |
| title | Phorbol ester-induced expression and function of the interleukin 2 receptor in human B lymphocytes. |
| title_full | Phorbol ester-induced expression and function of the interleukin 2 receptor in human B lymphocytes. |
| title_fullStr | Phorbol ester-induced expression and function of the interleukin 2 receptor in human B lymphocytes. |
| title_full_unstemmed | Phorbol ester-induced expression and function of the interleukin 2 receptor in human B lymphocytes. |
| title_short | Phorbol ester-induced expression and function of the interleukin 2 receptor in human B lymphocytes. |
| title_sort | phorbol ester induced expression and function of the interleukin 2 receptor in human b lymphocytes |
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