Biological relevance of DNA polymerase beta and translesion synthesis polymerases to cancer and its treatment

Biological relevance of DNA polymerase beta and translesion synthesis polymerases to cancer and its treatment

The cellular genome is constantly subject to DNA damage caused by endogenous factors or exogenously by damaging agents such as ionizing radiation or various anticancer agents. The base excision repair (BER) enzyme, DNA polymerase β, and the polymerases involved in translesion synthesis (TLS) have be...

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Détails bibliographiques
Auteurs principaux:	Nicolay, N, Helleday, T, Sharma, R
Format:	Journal article
Langue:	English
Publié:	2012

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