Biological relevance of DNA polymerase beta and translesion synthesis polymerases to cancer and its treatment

Biological relevance of DNA polymerase beta and translesion synthesis polymerases to cancer and its treatment

The cellular genome is constantly subject to DNA damage caused by endogenous factors or exogenously by damaging agents such as ionizing radiation or various anticancer agents. The base excision repair (BER) enzyme, DNA polymerase β, and the polymerases involved in translesion synthesis (TLS) have be...

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Detalhes bibliográficos
Principais autores:	Nicolay, N, Helleday, T, Sharma, R
Formato:	Journal article
Idioma:	English
Publicado em:	2012

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