Modelling multiscale aspects of colorectal cancer

Colorectal cancer (CRC) is responsible for nearly half a million deaths annually world-wide [11]. We present a series of mathematical models describing the dynamics of the intestinal epithelium and the kinetics of the molecular pathway most commonly mutated in CRC, the Wnt signalling network. We als...

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Main Authors: van Leeuwen, I, Byrne, H, Johnston, M, Edwards, C, Chapman, S, Bodmer, W, Maini, P
格式: Journal article
出版: 2008