Modelling multiscale aspects of colorectal cancer

Colorectal cancer (CRC) is responsible for nearly half a million deaths annually world-wide [11]. We present a series of mathematical models describing the dynamics of the intestinal epithelium and the kinetics of the molecular pathway most commonly mutated in CRC, the Wnt signalling network. We als...

Description complète

Détails bibliographiques
Auteurs principaux: van Leeuwen, I, Byrne, H, Johnston, M, Edwards, C, Chapman, S, Bodmer, W, Maini, P
Format: Journal article
Publié: 2008