Direct versatile route to conformationally constrained glutamate analogues
Novel conformationally constrained glutamate analogues are readily available from (S)-pyroglutamic acid; using a bicyclic lactam template, diastereocontrolled and sequential modification of the pyrrolidine ring is possible, allowing a versatile access to several glutamate and kainoid analogues; vari...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1998
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| _version_ | 1797085316100653056 |
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| author | Dyer, J Keeling, S Moloney, M |
| author_facet | Dyer, J Keeling, S Moloney, M |
| author_sort | Dyer, J |
| collection | OXFORD |
| description | Novel conformationally constrained glutamate analogues are readily available from (S)-pyroglutamic acid; using a bicyclic lactam template, diastereocontrolled and sequential modification of the pyrrolidine ring is possible, allowing a versatile access to several glutamate and kainoid analogues; variations in the C(2)H-C(3)H coupling constants were observed depending upon the nature of remote substituents on the heterocyclic ring, consistent with modification of the ring conformation. |
| first_indexed | 2024-03-07T02:07:13Z |
| format | Journal article |
| id | oxford-uuid:9f638452-5fb7-4cc0-bda2-d6540ef52933 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:07:13Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:9f638452-5fb7-4cc0-bda2-d6540ef529332022-03-27T00:57:22ZDirect versatile route to conformationally constrained glutamate analoguesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9f638452-5fb7-4cc0-bda2-d6540ef52933EnglishSymplectic Elements at Oxford1998Dyer, JKeeling, SMoloney, MNovel conformationally constrained glutamate analogues are readily available from (S)-pyroglutamic acid; using a bicyclic lactam template, diastereocontrolled and sequential modification of the pyrrolidine ring is possible, allowing a versatile access to several glutamate and kainoid analogues; variations in the C(2)H-C(3)H coupling constants were observed depending upon the nature of remote substituents on the heterocyclic ring, consistent with modification of the ring conformation. |
| spellingShingle | Dyer, J Keeling, S Moloney, M Direct versatile route to conformationally constrained glutamate analogues |
| title | Direct versatile route to conformationally constrained glutamate analogues |
| title_full | Direct versatile route to conformationally constrained glutamate analogues |
| title_fullStr | Direct versatile route to conformationally constrained glutamate analogues |
| title_full_unstemmed | Direct versatile route to conformationally constrained glutamate analogues |
| title_short | Direct versatile route to conformationally constrained glutamate analogues |
| title_sort | direct versatile route to conformationally constrained glutamate analogues |
| work_keys_str_mv | AT dyerj directversatileroutetoconformationallyconstrainedglutamateanalogues AT keelings directversatileroutetoconformationallyconstrainedglutamateanalogues AT moloneym directversatileroutetoconformationallyconstrainedglutamateanalogues |