State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1.

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1.

We previously reported that TREK-1 gating by internal pH and pressure occurs close to or within the selectivity filter. These conclusions were based upon kinetic measurements of high-affinity block by quaternary ammonium (QA) ions that appeared to exhibit state-independent accessibility to their bin...

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Príomhchruthaitheoirí:	Rapedius, M, Schmidt, MR, Sharma, C, Stansfeld, P, Sansom, MS, Baukrowitz, T, Tucker, S
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	2012

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