HLA antigens in severe pre-eclampsia.
When the HLA types of 80 pre-eclamptic women and their husbands and 83 control couples were compared significantly more pre-eclamptic women had only one identifiable HLA B antigen, and were presumed to be homozygous at this locus. Those who were homozygous for HLA B were more likely to be homozygous...
| Үндсэн зохиолчид: | , , , , |
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| Формат: | Journal article |
| Хэл сонгох: | English |
| Хэвлэсэн: |
1978
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| _version_ | 1826288045291208704 |
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| author | Redman, C Bodmer, J Bodmer, W Beilin, L Bonnar, J |
| author_facet | Redman, C Bodmer, J Bodmer, W Beilin, L Bonnar, J |
| author_sort | Redman, C |
| collection | OXFORD |
| description | When the HLA types of 80 pre-eclamptic women and their husbands and 83 control couples were compared significantly more pre-eclamptic women had only one identifiable HLA B antigen, and were presumed to be homozygous at this locus. Those who were homozygous for HLA B were more likely to be homozygous for HLA A as well, and more likely to be homozygous for HLA A as well, and to have more severe pre-eclampsia. There was neither increased HLA incompatibility nor greater antigen-sharing between pre-eclamptic women and their husbands, but maternal HLA A and B homozygosity reduced the number of antigenic disparities between pre-eclamptic women and their husbands. The data are consistent with the hypothesis that maternal recessive immune-response genes may contribute to the development of pre-eclampsia. Alternatively maternal HLA homozygosity may predispose to fetal changes comparable to runting. |
| first_indexed | 2024-03-07T02:07:47Z |
| format | Journal article |
| id | oxford-uuid:9f95f0ce-2deb-4c55-ba4d-ca8b76b03e9c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:07:47Z |
| publishDate | 1978 |
| record_format | dspace |
| spelling | oxford-uuid:9f95f0ce-2deb-4c55-ba4d-ca8b76b03e9c2022-03-27T00:58:54ZHLA antigens in severe pre-eclampsia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9f95f0ce-2deb-4c55-ba4d-ca8b76b03e9cEnglishSymplectic Elements at Oxford1978Redman, CBodmer, JBodmer, WBeilin, LBonnar, JWhen the HLA types of 80 pre-eclamptic women and their husbands and 83 control couples were compared significantly more pre-eclamptic women had only one identifiable HLA B antigen, and were presumed to be homozygous at this locus. Those who were homozygous for HLA B were more likely to be homozygous for HLA A as well, and more likely to be homozygous for HLA A as well, and to have more severe pre-eclampsia. There was neither increased HLA incompatibility nor greater antigen-sharing between pre-eclamptic women and their husbands, but maternal HLA A and B homozygosity reduced the number of antigenic disparities between pre-eclamptic women and their husbands. The data are consistent with the hypothesis that maternal recessive immune-response genes may contribute to the development of pre-eclampsia. Alternatively maternal HLA homozygosity may predispose to fetal changes comparable to runting. |
| spellingShingle | Redman, C Bodmer, J Bodmer, W Beilin, L Bonnar, J HLA antigens in severe pre-eclampsia. |
| title | HLA antigens in severe pre-eclampsia. |
| title_full | HLA antigens in severe pre-eclampsia. |
| title_fullStr | HLA antigens in severe pre-eclampsia. |
| title_full_unstemmed | HLA antigens in severe pre-eclampsia. |
| title_short | HLA antigens in severe pre-eclampsia. |
| title_sort | hla antigens in severe pre eclampsia |
| work_keys_str_mv | AT redmanc hlaantigensinseverepreeclampsia AT bodmerj hlaantigensinseverepreeclampsia AT bodmerw hlaantigensinseverepreeclampsia AT beilinl hlaantigensinseverepreeclampsia AT bonnarj hlaantigensinseverepreeclampsia |