Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project

Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project

Testicular germ cell tumours (TGCT), which comprise seminoma and non-seminoma subtypes, are the most common cancers in young men. In this study, we present a comprehensive whole genome sequencing analysis of adult TGCTs. Leveraging samples from participants recruited via the UK National Health Servi...

Descripció completa

Dades bibliogràfiques
Autors principals:	Ní Leathlobhair, M, Frangou, A, Kinnersley, B, Cornish, AJ, Chubb, D, Lakatos, E, Arumugam, P, Gruber, AJ, Law, P, Tapinos, A, Jakobsdottir, GM, Peneva, I, Sahli, A, Smyth, EM, Ball, RY, Sylva, R, Benes, K, Stark, D, Young, RJ, Lee, ATJ, Wolverson, V, Houlston, RS, Sosinsky, A, Protheroe, A, Wedge, DC, Verrill, C
Format:	Journal article
Idioma:	English
Publicat:	Nature Research 2024

Ítems similars

Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project
per: Máire Ní Leathlobhair, et al.
Publicat: (2024-10-01)

Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology
per: Kinnersley, B, et al.
Publicat: (2024)

Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma
per: Culliford, R, et al.
Publicat: (2024)

The genomic landscape of 2,023 colorectal cancers
per: Cornish, AJ, et al.
Publicat: (2024)

The UK’s 100,000 Genomes Project: manifesting policymakers’ expectations
per: Gabrielle Natalie Samuel, et al.
Publicat: (2017-10-01)

Clinical whole-genome sequencing from routine formalin-fixed, paraffin-embedded specimens: pilot study for the 100,000 Genomes Project.
per: Robbe, P, et al.
Publicat: (2018)

Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma
per: Richard Culliford, et al.
Publicat: (2024-07-01)

Understanding experiences of recruiting for, and participating in, genomics research and service transformation: the 100,000 Genomes Project, 2015-17
per: Ryan, S, et al.
Publicat: (2020)

The 100,000 genomes pilot on rare disease diagnosis in healthcare – a preliminary report
per: Smedley, D, et al.
Publicat: (2021)

Opportunities and Challenges for Molecular Understanding of Ciliopathies–The 100,000 Genomes Project
per: Gabrielle Wheway, et al.
Publicat: (2019-03-01)

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
per: Zachary R. Chalmers, et al.
Publicat: (2017-04-01)

Corrigendum: Opportunities and Challenges for Molecular Understanding of Ciliopathies–The 100,000 Genomes Project
per: Gabrielle Wheway, et al.
Publicat: (2019-08-01)

BlastFrost: fast querying of 100,000s of bacterial genomes in Bifrost graphs
per: Nina Luhmann, et al.
Publicat: (2021-01-01)

Prognosis and oncogenomic profiling of patients with tropomyosin receptor kinase fusion cancer in the 100,000 genomes project
per: John Bridgewater, et al.
Publicat: (2022-01-01)

Increasing the diagnostic yield of childhood glaucoma cases recruited into the 100,000 Genomes Project
per: Omayma Al-Saei, et al.
Publicat: (2024-05-01)

A systematic analysis of splicing variants identifies new diagnoses in the 100,000 Genomes Project
per: Alexander J. M. Blakes, et al.
Publicat: (2022-07-01)

A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores
per: Moonil Kang, et al.
Publicat: (2023-06-01)

Potential for diagnosis of infectious disease from the 100,000 Genomes Project Metagenomic Dataset: recommendations for reporting results
per: Magiorkinis, G, et al.
Publicat: (2019)

Identification of FH-causing variants in patients with clinical familial hypercholesterolaemia recruited into the 100,000 genome project: preliminary analysis
per: A. Rimbert, et al.
Publicat: (2021-09-01)

APOBEC3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types
per: G. Maria Jakobsdottir, et al.
Publicat: (2022-05-01)

Nanoscopy with more than 100,000 'doughnuts'.
per: Chmyrov, A, et al.
Publicat: (2013)

Cardiomyopathies in 100,000 genomes project: interval evaluation improves diagnostic yield and informs strategies for ongoing gene discovery
per: Katherine S. Josephs, et al.
Publicat: (2024-10-01)

Association between tumour somatic mutations and venous thromboembolism in the 100,000 Genomes Project cancer cohort: a study protocol [version 2; peer review: 2 approved]
per: Naomi Cornish, et al.
Publicat: (2024-12-01)

Edar 100000 topeng muka
per: UMP, .
Publicat: (2015)

A signal processing method for alignment-free metagenomic binning: multi-resolution genomic binary patterns
per: Kouchaki, S, et al.
Publicat: (2019)

Nanoscopy with more than 100,000 'doughnuts'
per: Chmyrov, A, et al.
Publicat: (2013)

“Not pathogenic until proven otherwise”: perspectives of UK clinical genomics professionals toward secondary findings in context of a Genomic Medicine Multidisciplinary Team and the 100,000 Genomes Project
per: Ormondroyd, E, et al.
Publicat: (2017)

Using data from the 100,000 Genomes Project to resolve conflicting interpretations of a recurrent TUBB2A mutation
per: Ragoussis, V, et al.
Publicat: (2021)

The use of biomedical big data for economic analyses of genome sequencing in rare genetic diseases: a case study from the 100,000 Genomes Project
per: Fahr, P
Publicat: (2021)

Increased COVID-19 mortality rate in rare disease patients: a retrospective cohort study in participants of the Genomics England 100,000 Genomes project
per: Huayu Zhang, et al.
Publicat: (2022-04-01)

UPM sasar 100,000 pengunjung
per: Utusan Malaysia,
Publicat: (2015)

100,000 warga emas terpinggir
per: Utusan Malaysia, Noraini Nordin
Publicat: (2009)

Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes
per: Ansari-Pour, N, et al.
Publicat: (2021)

Validation of Recently Proposed Colorectal Cancer Susceptibility Gene Variants in an Analysis of Families and Patients-a Systematic Review.
per: Broderick, P, et al.
Publicat: (2016)

Prognostic determinants in cancer survival: a multidimensional evaluation of clinical and genetic factors across 10 cancer types in the participants of Genomics England’s 100,000 Genomes Project
per: Jurgita Gammall, et al.
Publicat: (2024-09-01)

Genetic landscape of interval and screen detected breast cancer
per: Charlie Mills, et al.
Publicat: (2024-05-01)

RM100,000 untuk Cendekia Bitara
per: Nur Akhmar, Mohd Abhar
Publicat: (2009)

Huawei latih 100,000 profesional ICT
per: Harian Metro,
Publicat: (2012)

Zero to 100,000 : social media tips and tricks for small business /
per: 531650 Gratton, Sarah-Jayne, et al.
Publicat: (c201)

Protocol and quality assurance for carotid imaging in 100,000 participants of UK Biobank: development and assessment.
per: Coffey, S, et al.
Publicat: (2017)