Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.

Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.

Although several cancer immunotherapy strategies are based on the use of analog peptides and on the modulation of the TCR affinity of adoptively transferred T cells, it remains unclear whether tumor-specific T cell activation by strong and weak TCR stimuli evoke different Ca(2+) signatures from the...

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Detalles Bibliográficos
Main Authors: Chen, J, Morgan, A, Stewart-Jones, G, Shepherd, D, Bossi, G, Wooldridge, L, Hutchinson, S, Sewell, A, Griffiths, G, Van Der Merwe, P, Jones, E, Galione, A, Cerundolo, V
Formato: Journal article
Idioma:English
Publicado: 2010

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