Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s disease
<p>Resting-state fMRI (rs-fMRI) dysfunction within the basal ganglia network (BGN) is a feature of early Parkinson’s disease (Szewczyk-Krolikowski et al., 2014, Rolinski et al., 2015), and may be a diagnostic biomarker of basal ganglia dysfunction. Currently, it is unclear whether these change...
| Hlavní autoři: | , , , , , , , , , , |
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| Médium: | Journal article |
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Oxford University Press
2016
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| _version_ | 1826288074345152512 |
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| author | Rolinski, M Griffanti, L Piccini, P Roussakis, A Szewczyk-Krolikowski, K Menke, R Quinnell, T Zaiwalla, Z Klein, J Mackay, C Hu, M |
| author_facet | Rolinski, M Griffanti, L Piccini, P Roussakis, A Szewczyk-Krolikowski, K Menke, R Quinnell, T Zaiwalla, Z Klein, J Mackay, C Hu, M |
| author_sort | Rolinski, M |
| collection | OXFORD |
| description | <p>Resting-state fMRI (rs-fMRI) dysfunction within the basal ganglia network (BGN) is a feature of early Parkinson’s disease (Szewczyk-Krolikowski et al., 2014, Rolinski et al., 2015), and may be a diagnostic biomarker of basal ganglia dysfunction. Currently, it is unclear whether these changes are present in so-called idiopathic rapid eye movement sleep behaviour disorder (RBD), a condition associated with a high rate of future conversion to Parkinson’s. In this study, we explore the utility of rs-fMRI to detect BGN dysfunction in RBD. We compare these data to a set of healthy controls, and to a set of patients with established early Parkinson’s. Furthermore, we explore the relationship between rs-fMRI BGN dysfunction and loss of dopaminergic neurons assessed with dopamine transporter single photon emission computerised tomography (SPECT), and perform morphometric analyses to assess grey matter loss.</p> <p>26 patients with polysomnographically established RBD, 48 Parkinson’s patients and 23 healthy controls were included in this study. Resting-state networks were isolated from task-free fMRI data using dual regression with a template was derived from a separate cohort of 80 elderly HC participants. Rs-fMRI parameter estimates were extracted from the study subjects in the BGN. In addition, 8 RBD, 10 Parkinson’s and 10 control subjects received 123I-ioflupane SPECT. We tested for reduction of BGN connectivity, and for loss of tracer uptake in RBD and Parkinson’s relative to each other and to controls.</p> <p>Connectivity measures of BGN network dysfunction differentiated both RBD and Parkinson’s from controls with high sensitivity (96%) and specificity (74% for RBD, 78% for PD), indicating its potential as an indicator of early basal ganglia dysfunction. RBD was indistinguishable from Parkinson’s on rs-fMRI despite obvious differences on dopamine transported SPECT.</p> <p>Basal ganglia connectivity is a promising biomarker for the detection of early BGN dysfunction, and may help to identify patients at risk of developing Parkinson’s in the future. Future risk stratification using a polymodal approach could combine BGN connectivity with clinical and other imaging measures, with important implications for future neuroprotective trials in RBD.</p> |
| first_indexed | 2024-03-07T02:08:14Z |
| format | Journal article |
| id | oxford-uuid:9fb848e8-90fb-485b-b5f4-0d7bcb9e7a1f |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:08:14Z |
| publishDate | 2016 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:9fb848e8-90fb-485b-b5f4-0d7bcb9e7a1f2022-03-27T00:59:59ZBasal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9fb848e8-90fb-485b-b5f4-0d7bcb9e7a1fSymplectic Elements at OxfordOxford University Press2016Rolinski, MGriffanti, LPiccini, PRoussakis, ASzewczyk-Krolikowski, KMenke, RQuinnell, TZaiwalla, ZKlein, JMackay, CHu, M<p>Resting-state fMRI (rs-fMRI) dysfunction within the basal ganglia network (BGN) is a feature of early Parkinson’s disease (Szewczyk-Krolikowski et al., 2014, Rolinski et al., 2015), and may be a diagnostic biomarker of basal ganglia dysfunction. Currently, it is unclear whether these changes are present in so-called idiopathic rapid eye movement sleep behaviour disorder (RBD), a condition associated with a high rate of future conversion to Parkinson’s. In this study, we explore the utility of rs-fMRI to detect BGN dysfunction in RBD. We compare these data to a set of healthy controls, and to a set of patients with established early Parkinson’s. Furthermore, we explore the relationship between rs-fMRI BGN dysfunction and loss of dopaminergic neurons assessed with dopamine transporter single photon emission computerised tomography (SPECT), and perform morphometric analyses to assess grey matter loss.</p> <p>26 patients with polysomnographically established RBD, 48 Parkinson’s patients and 23 healthy controls were included in this study. Resting-state networks were isolated from task-free fMRI data using dual regression with a template was derived from a separate cohort of 80 elderly HC participants. Rs-fMRI parameter estimates were extracted from the study subjects in the BGN. In addition, 8 RBD, 10 Parkinson’s and 10 control subjects received 123I-ioflupane SPECT. We tested for reduction of BGN connectivity, and for loss of tracer uptake in RBD and Parkinson’s relative to each other and to controls.</p> <p>Connectivity measures of BGN network dysfunction differentiated both RBD and Parkinson’s from controls with high sensitivity (96%) and specificity (74% for RBD, 78% for PD), indicating its potential as an indicator of early basal ganglia dysfunction. RBD was indistinguishable from Parkinson’s on rs-fMRI despite obvious differences on dopamine transported SPECT.</p> <p>Basal ganglia connectivity is a promising biomarker for the detection of early BGN dysfunction, and may help to identify patients at risk of developing Parkinson’s in the future. Future risk stratification using a polymodal approach could combine BGN connectivity with clinical and other imaging measures, with important implications for future neuroprotective trials in RBD.</p> |
| spellingShingle | Rolinski, M Griffanti, L Piccini, P Roussakis, A Szewczyk-Krolikowski, K Menke, R Quinnell, T Zaiwalla, Z Klein, J Mackay, C Hu, M Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s disease |
| title | Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s disease |
| title_full | Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s disease |
| title_fullStr | Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s disease |
| title_full_unstemmed | Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s disease |
| title_short | Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s disease |
| title_sort | basal ganglia dysfunction in idiopathic rem sleep behaviour disorder parallels that in early parkinson s disease |
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