Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo.

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo.

While small interfering RNAs (siRNAs) have been rapidly appreciated to silence genes, efficient and non-toxic vectors for primary cells and for systemic in vivo delivery are lacking. Several siRNA-delivery vehicles, including cell-penetrating peptides (CPPs), have been developed but their utility is...

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Bibliographic Details
Main Authors: Andaloussi, SE, Lehto, T, Mäger, I, Rosenthal-Aizman, K, Oprea, I, Simonson, O, Sork, H, Ezzat, K, Copolovici, D, Kurrikoff, K, Viola, JR, Zaghloul, E, Sillard, R, Johansson, H, Said Hassane, F, Guterstam, P, Suhorutšenko, J, Moreno, P, Oskolkov, N, Hälldin, J, Tedebark, U, Metspalu, A, Lebleu, B, Lehtiö, J, Smith, C
Format: Journal article
Language:English
Published: 2011

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