Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2p12-q11.
Schizophrenia and non-right-handedness are moderately associated, and both traits are often accompanied by abnormalities of asymmetrical brain morphology or function. We have found linkage previously of chromosome 2p12-q11 to a quantitative measure of handedness, and we have also found linkage of sc...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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| _version_ | 1797085414923698176 |
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| author | Francks, C DeLisi, L Shaw, S Fisher, S Richardson, A Stein, J Monaco, A |
| author_facet | Francks, C DeLisi, L Shaw, S Fisher, S Richardson, A Stein, J Monaco, A |
| author_sort | Francks, C |
| collection | OXFORD |
| description | Schizophrenia and non-right-handedness are moderately associated, and both traits are often accompanied by abnormalities of asymmetrical brain morphology or function. We have found linkage previously of chromosome 2p12-q11 to a quantitative measure of handedness, and we have also found linkage of schizophrenia/schizoaffective disorder to this same chromosomal region in a separate study. Now, we have found that in one of our samples (191 reading-disabled sibling pairs), the relative hand skill of siblings was correlated more strongly with paternal than maternal relative hand skill. This led us to re-analyse 2p12-q11 under parent-of-origin linkage models. We found linkage of relative hand skill in the RD siblings to 2p12-q11 with P=0.0000037 for paternal identity-by-descent sharing, whereas the maternally inherited locus was not linked to the trait (P>0.2). Similarly, in affected-sib-pair analysis of our schizophrenia dataset (241 sibling pairs), we found linkage to schizophrenia for paternal sharing with LOD=4.72, P=0.0000016, within 3 cM of the peak linkage to relative hand skill. Maternal linkage across the region was weak or non-significant. These similar paternal-specific linkages suggest that the causative genetic effects on 2p12-q11 are related. The linkages may be due to a single maternally imprinted influence on lateralized brain development that contains common functional polymorphisms. |
| first_indexed | 2024-03-07T02:08:40Z |
| format | Journal article |
| id | oxford-uuid:9fd9a3ee-e70b-4275-ace4-ec07386df8bd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:08:40Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:9fd9a3ee-e70b-4275-ace4-ec07386df8bd2022-03-27T02:01:06ZParent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2p12-q11.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9fd9a3ee-e70b-4275-ace4-ec07386df8bdEnglishSymplectic Elements at Oxford2003Francks, CDeLisi, LShaw, SFisher, SRichardson, AStein, JMonaco, ASchizophrenia and non-right-handedness are moderately associated, and both traits are often accompanied by abnormalities of asymmetrical brain morphology or function. We have found linkage previously of chromosome 2p12-q11 to a quantitative measure of handedness, and we have also found linkage of schizophrenia/schizoaffective disorder to this same chromosomal region in a separate study. Now, we have found that in one of our samples (191 reading-disabled sibling pairs), the relative hand skill of siblings was correlated more strongly with paternal than maternal relative hand skill. This led us to re-analyse 2p12-q11 under parent-of-origin linkage models. We found linkage of relative hand skill in the RD siblings to 2p12-q11 with P=0.0000037 for paternal identity-by-descent sharing, whereas the maternally inherited locus was not linked to the trait (P>0.2). Similarly, in affected-sib-pair analysis of our schizophrenia dataset (241 sibling pairs), we found linkage to schizophrenia for paternal sharing with LOD=4.72, P=0.0000016, within 3 cM of the peak linkage to relative hand skill. Maternal linkage across the region was weak or non-significant. These similar paternal-specific linkages suggest that the causative genetic effects on 2p12-q11 are related. The linkages may be due to a single maternally imprinted influence on lateralized brain development that contains common functional polymorphisms. |
| spellingShingle | Francks, C DeLisi, L Shaw, S Fisher, S Richardson, A Stein, J Monaco, A Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2p12-q11. |
| title | Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2p12-q11. |
| title_full | Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2p12-q11. |
| title_fullStr | Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2p12-q11. |
| title_full_unstemmed | Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2p12-q11. |
| title_short | Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2p12-q11. |
| title_sort | parent of origin effects on handedness and schizophrenia susceptibility on chromosome 2p12 q11 |
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