Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation

Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation

Signaling through the T cell receptor (TCR) initiates adaptive immunity and its perturbation may results in autoimmunity. The plasma membrane scaffolding protein LAT acts as a central organizer of the TCR signaling machinery to activate many functional pathways. LAT-deficient mice develop an autoimm...

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Bibliographic Details
Main Authors:	Salek, M, McGowan, S, Trudgian, D, Dushek, O, De Wet, B, Efstathiou, G, Acuto, O
Format:	Journal article
Language:	English
Published:	Public Library of Science 2013

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