Natural killer T cells: an ecological evolutionary developmental biology perspective
Type I natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens presented by the MHC class I-like protein CD1d. Agonistic activation of NKT cells leads to rapid pro-inflammatory and immune modulatory cytokine and chemokine responses. This property of NKT cells, i...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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Frontiers Media
2017
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| _version_ | 1826288134555435008 |
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| author | Kumar, A Suryadevara, N Hill, T Bezbradica, J Van Kaer, L Joyce, S |
| author_facet | Kumar, A Suryadevara, N Hill, T Bezbradica, J Van Kaer, L Joyce, S |
| author_sort | Kumar, A |
| collection | OXFORD |
| description | Type I natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens presented by the MHC class I-like protein CD1d. Agonistic activation of NKT cells leads to rapid pro-inflammatory and immune modulatory cytokine and chemokine responses. This property of NKT cells, in conjunction with their interactions with antigen-presenting cells, controls downstream innate and adaptive immune responses against cancers and infectious diseases, as well as in several inflammatory disorders. NKT cell properties are acquired during development in the thymus and by interactions with the host microbial consortium in the gut, the nature of which can be influenced by NKT cells. This latter property, together with the role of the host microbiota in cancer therapy, necessitates a new perspective. Hence, this review provides an initial approach to understanding NKT cells from an ecological evolutionary developmental biology (eco-evo-devo) perspective. |
| first_indexed | 2024-03-07T02:09:08Z |
| format | Journal article |
| id | oxford-uuid:a000295b-86df-4092-a1c3-37acbcedecc5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:09:08Z |
| publishDate | 2017 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:a000295b-86df-4092-a1c3-37acbcedecc52022-03-27T02:02:21ZNatural killer T cells: an ecological evolutionary developmental biology perspectiveJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a000295b-86df-4092-a1c3-37acbcedecc5EnglishSymplectic Elements at OxfordFrontiers Media2017Kumar, ASuryadevara, NHill, TBezbradica, JVan Kaer, LJoyce, SType I natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens presented by the MHC class I-like protein CD1d. Agonistic activation of NKT cells leads to rapid pro-inflammatory and immune modulatory cytokine and chemokine responses. This property of NKT cells, in conjunction with their interactions with antigen-presenting cells, controls downstream innate and adaptive immune responses against cancers and infectious diseases, as well as in several inflammatory disorders. NKT cell properties are acquired during development in the thymus and by interactions with the host microbial consortium in the gut, the nature of which can be influenced by NKT cells. This latter property, together with the role of the host microbiota in cancer therapy, necessitates a new perspective. Hence, this review provides an initial approach to understanding NKT cells from an ecological evolutionary developmental biology (eco-evo-devo) perspective. |
| spellingShingle | Kumar, A Suryadevara, N Hill, T Bezbradica, J Van Kaer, L Joyce, S Natural killer T cells: an ecological evolutionary developmental biology perspective |
| title | Natural killer T cells: an ecological evolutionary developmental biology perspective |
| title_full | Natural killer T cells: an ecological evolutionary developmental biology perspective |
| title_fullStr | Natural killer T cells: an ecological evolutionary developmental biology perspective |
| title_full_unstemmed | Natural killer T cells: an ecological evolutionary developmental biology perspective |
| title_short | Natural killer T cells: an ecological evolutionary developmental biology perspective |
| title_sort | natural killer t cells an ecological evolutionary developmental biology perspective |
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