Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin.

Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin.

The mode of binding of oligosaccharides to griffithsin, an antiviral lectin from the red alga Griffithsia sp., was investigated by a combination of X-ray crystallography, isothermal titration calorimetry, and molecular modeling. The structures of complexes of griffithsin with 1-->6alpha-manno...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Ziółkowska, N, Shenoy, SR, O'Keefe, B, McMahon, J, Palmer, K, Dwek, R, Wormald, M, Wlodawer, A
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2007

समान संसाधन

Hantavirus Infection Is Inhibited by Griffithsin in Cell Culture
द्वारा: Punya Shrivastava-Ranjan, और अन्य
प्रकाशित: (2020-11-01)

Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential
द्वारा: Sabrina Lusvarghi, और अन्य
प्रकाशित: (2016-10-01)

Expression and antiviral application of exogenous lectin (griffithsin) in sweetpotatoes
द्वारा: Shuai Liu, और अन्य
प्रकाशित: (2024-07-01)

Novel Antifungal Activity of Q-Griffithsin, a Broad-Spectrum Antiviral Lectin
द्वारा: Henry W. Nabeta, और अन्य
प्रकाशित: (2021-10-01)

Antiviral lectin Q-Griffithsin suppresses fungal infection in murine models of vaginal candidiasis
द्वारा: Henry W. Nabeta, और अन्य
प्रकाशित: (2022-10-01)

Griffithsin, a Highly Potent Broad-Spectrum Antiviral Lectin from Red Algae: From Discovery to Clinical Application
द्वारा: Choongho Lee
प्रकाशित: (2019-10-01)

Griffithsin and Carrageenan Combination Results in Antiviral Synergy against SARS-CoV-1 and 2 in a Pseudoviral Model
द्वारा: Sahar Alsaidi, और अन्य
प्रकाशित: (2021-07-01)

Technoeconomic Modeling of Plant-Based Griffithsin Manufacturing
द्वारा: Aatif Alam, और अन्य
प्रकाशित: (2018-07-01)

Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate.
द्वारा: Joseph Calvin Kouokam, और अन्य
प्रकाशित: (2011-01-01)

The Antiviral Activity of the Lectin Griffithsin against SARS-CoV-2 Is Enhanced by the Presence of Structural Proteins
द्वारा: Arjan Bains, और अन्य
प्रकाशित: (2023-12-01)

Synergistic anti-HIV-1 activity of griffithsin with tenofovir, maraviroc and enfuvirtide
द्वारा: Schols Dominique, और अन्य
प्रकाशित: (2011-10-01)

Applied and implied semantics in crystallographic publishing
द्वारा: McMahon Brian
प्रकाशित: (2012-08-01)

Heterologous Expression of the Antiviral Lectin Griffithsin in Probiotic <i>Saccharomyces boulardii</i> and In Vitro Characterization of Its Properties
द्वारा: Jie Tang, और अन्य
प्रकाशित: (2024-11-01)

The Crystallographic Information File (CIF)
द्वारा: I D Brown, और अन्य
प्रकाशित: (2006-11-01)

Inhibition of influenza A virus and SARS-CoV-2 infection or co-infection by griffithsin and griffithsin-based bivalent entry inhibitor
द्वारा: Najing Cao, और अन्य
प्रकाशित: (2024-05-01)

Exploring functions for glycosylation in host defence using novel oligosaccharide sequencing technology
द्वारा: Rudd, P, और अन्य
प्रकाशित: (2000)

Algal Lectin Griffithsin Inhibits Ebola Virus Infection
द्वारा: Leah Liu Wang, और अन्य
प्रकाशित: (2025-02-01)

Role of the carbohydrate-binding sites of griffithsin in the prevention of DC-SIGN-mediated capture and transmission of HIV-1.
द्वारा: Bart Hoorelbeke, और अन्य
प्रकाशित: (2013-01-01)

Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo
द्वारा: Nina Derby, और अन्य
प्रकाशित: (2018-09-01)

The interoperability of crystallographic data and databases
द्वारा: Alice Brink, और अन्य
प्रकाशित: (2024-01-01)

In Preparation for Outdoor Pharming: Griffithsin Can Be Expressed in Nicotiana excelsiana and Retains Activity After Storage as Silage
द्वारा: Paul Eapen, और अन्य
प्रकाशित: (2020-03-01)

An algal lectin griffithsin inhibits Hantaan virus infection in vitro and in vivo
द्वारा: Yajing Zhao, और अन्य
प्रकाशित: (2022-12-01)

Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus.
द्वारा: Yutaka Takebe, और अन्य
प्रकाशित: (2013-01-01)

In vitro Study on Synergistic Interactions Between Free and Encapsulated Q-Griffithsin and Antiretrovirals Against HIV-1 Infection
द्वारा: Minooei F, और अन्य
प्रकाशित: (2021-02-01)

Potent fluoro-oligosaccharide probes of adhesion in Toxoplasmosis.
द्वारा: Allman, SA, और अन्य
प्रकाशित: (2009)

Conformational studies of oligosaccharides and glycopeptides: complementarity of NMR, X-ray crystallography, and molecular modelling.
द्वारा: Wormald, M, और अन्य
प्रकाशित: (2002)

Development and validation of a product acceptability questionnaire for intranasal Q-Griffithsin COVID-19 prophylaxis (SPRAY PAL)
द्वारा: Elizabeth Cash, और अन्य
प्रकाशित: (2023-09-01)

Mannose-Binding Lectins as Potent Antivirals against SARS-CoV-2
द्वारा: Victória Riquena Grosche, और अन्य
प्रकाशित: (2023-09-01)

Studies in a Murine Model Confirm the Safety of Griffithsin and Advocate Its Further Development as a Microbicide Targeting HIV-1 and Other Enveloped Viruses
द्वारा: Joseph Calvin Kouokam, और अन्य
प्रकाशित: (2016-11-01)

ALPHA-MANNOSIDASE-CATALYZED SYNTHESIS OF NOVEL MANNO-OLIGOSACCHARIDES, LYXO-OLIGOSACCHARIDES, AND HETEROMANNO-OLIGOSACCHARIDES - A COMPARISON OF KINETICALLY AND THERMODYNAMICALLY MEDIATED APPROACHES
द्वारा: Rastall, R, और अन्य
प्रकाशित: (1992)

Grifonin-1: a small HIV-1 entry inhibitor derived from the algal lectin, Griffithsin.
द्वारा: Ewa D Micewicz, और अन्य
प्रकाशित: (2010-12-01)

From X-ray crystallographic structure to intrinsic thermodynamics of protein–ligand binding using carbonic anhydrase isozymes as a model system
द्वारा: Vaida Paketurytė-Latvė, और अन्य
प्रकाशित: (2024-07-01)

Design of Poly(lactic-<i>co</i>-glycolic Acid) (PLGA) Nanoparticles for Vaginal Co-Delivery of Griffithsin and Dapivirine and Their Synergistic Effect for HIV Prophylaxis
द्वारा: Haitao Yang, और अन्य
प्रकाशित: (2019-04-01)

Crystallographic and Biochemical Analysis of the Ran-Binding Zinc Finger Domain
द्वारा: Partridge, James R., और अन्य
प्रकाशित: (2012)

Crystallographic and in silico analysis of the sialoside-binding characteristics of the Siglec sialoadhesin.
द्वारा: Zaccai, N, और अन्य
प्रकाशित: (2007)

Cellular effects of deoxynojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides.
द्वारा: Mellor, H, और अन्य
प्रकाशित: (2004)

Thermodynamic Properties and Crystallographic Characterization of Semiclathrate Hydrates Formed with Tetra‑n‑butylammonium Glycolate
द्वारा: Sanehiro Muromachi, और अन्य
प्रकाशित: (2019-04-01)

Targeted Delivery of Nanovaccine to Dendritic Cells via DC-Binding Peptides Induces Potent Antiviral Immunity in vivo
द्वारा: Lu Y, और अन्य
प्रकाशित: (2022-04-01)

Crystallographic models of SARS-CoV-2 3CLpro: in-depth assessment of structure quality and validation
द्वारा: Mariusz Jaskolski, और अन्य
प्रकाशित: (2021-03-01)

Assessment of repurposed compounds against coronaviruses highlights the antiviral broad-spectrum activity of host-targeting iminosugars and confirms the activity of potent directly acting antivirals
द्वारा: Brun, J, और अन्य
प्रकाशित: (2025)