Malarial anemia: of mice and men.
Severe malaria is manifest by a variety of clinical syndromes dependent on properties of both the host and the parasite. In young infants, severe malarial anemia (SMA) is the most common syndrome of severe disease and contributes substantially to the considerable mortality and morbidity from malaria...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1826288145660903424 |
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| author | Lamikanra, A Brown, D Potocnik, A Casals-Pascual, C Langhorne, J Roberts, D |
| author_facet | Lamikanra, A Brown, D Potocnik, A Casals-Pascual, C Langhorne, J Roberts, D |
| author_sort | Lamikanra, A |
| collection | OXFORD |
| description | Severe malaria is manifest by a variety of clinical syndromes dependent on properties of both the host and the parasite. In young infants, severe malarial anemia (SMA) is the most common syndrome of severe disease and contributes substantially to the considerable mortality and morbidity from malaria. There is now growing evidence, from both human and mouse studies of malaria, to show that anemia is due not only to increased hemolysis of infected and clearance of uninfected red blood cells (RBCs) but also to an inability of the infected host to produce an adequate erythroid response. In this review, we will summarize the recent clinical and experimental studies of malaria to highlight similarities and differences in human and mouse pathology that result in anemia and so inform the use of mouse models in the study of severe malarial anemia in humans. |
| first_indexed | 2024-03-07T02:09:18Z |
| format | Journal article |
| id | oxford-uuid:a00fbd46-827b-4e94-b27a-56c545991e0f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:09:18Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:a00fbd46-827b-4e94-b27a-56c545991e0f2022-03-27T02:02:41ZMalarial anemia: of mice and men.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a00fbd46-827b-4e94-b27a-56c545991e0fEnglishSymplectic Elements at Oxford2007Lamikanra, ABrown, DPotocnik, ACasals-Pascual, CLanghorne, JRoberts, DSevere malaria is manifest by a variety of clinical syndromes dependent on properties of both the host and the parasite. In young infants, severe malarial anemia (SMA) is the most common syndrome of severe disease and contributes substantially to the considerable mortality and morbidity from malaria. There is now growing evidence, from both human and mouse studies of malaria, to show that anemia is due not only to increased hemolysis of infected and clearance of uninfected red blood cells (RBCs) but also to an inability of the infected host to produce an adequate erythroid response. In this review, we will summarize the recent clinical and experimental studies of malaria to highlight similarities and differences in human and mouse pathology that result in anemia and so inform the use of mouse models in the study of severe malarial anemia in humans. |
| spellingShingle | Lamikanra, A Brown, D Potocnik, A Casals-Pascual, C Langhorne, J Roberts, D Malarial anemia: of mice and men. |
| title | Malarial anemia: of mice and men. |
| title_full | Malarial anemia: of mice and men. |
| title_fullStr | Malarial anemia: of mice and men. |
| title_full_unstemmed | Malarial anemia: of mice and men. |
| title_short | Malarial anemia: of mice and men. |
| title_sort | malarial anemia of mice and men |
| work_keys_str_mv | AT lamikanraa malarialanemiaofmiceandmen AT brownd malarialanemiaofmiceandmen AT potocnika malarialanemiaofmiceandmen AT casalspascualc malarialanemiaofmiceandmen AT langhornej malarialanemiaofmiceandmen AT robertsd malarialanemiaofmiceandmen |