Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice.
Lymphocytic choriomeningitis virus (LCMV), strain WE, is a non-cytopathic RNA virus that is highly adapted to its natural host, the mouse. Acute infection of adult mice leads to generalized virus spread, followed by cytotoxic T lymphocyte-mediated virus clearance below the detection levels of conven...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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| _version_ | 1797085474139930624 |
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| author | Ciurea, A Klenerman, P Hunziker, L Horvath, E Odermatt, B Ochsenbein, A Hengartner, H Zinkernagel, R |
| author_facet | Ciurea, A Klenerman, P Hunziker, L Horvath, E Odermatt, B Ochsenbein, A Hengartner, H Zinkernagel, R |
| author_sort | Ciurea, A |
| collection | OXFORD |
| description | Lymphocytic choriomeningitis virus (LCMV), strain WE, is a non-cytopathic RNA virus that is highly adapted to its natural host, the mouse. Acute infection of adult mice leads to generalized virus spread, followed by cytotoxic T lymphocyte-mediated virus clearance below the detection levels of conventional assays within 2-3 weeks. Indirect evidence had suggested that virus or viral antigen might persist in the immune mouse. Here we demonstrate LCMV-WE persistence at low levels after infection with 10(2) or 10(6) plaque-forming units, shown as viral genome, viral antigen, and replicative virus using sensitive in vitro and in vivo assays. The finding that LCMV-WE persists in the face of apparently intact immune responses resembles the situation in some viral (hepatitis B and C, HIV) and bacterial (tuberculosis, leprosy) infections in humans; the results are relevant to the understanding not only of other murine and human persistent viral infections but also of protective immunological memory by "infection immunity." |
| first_indexed | 2024-03-07T02:09:21Z |
| format | Journal article |
| id | oxford-uuid:a013cdad-735f-49b3-945a-d33ef136102e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:09:21Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:a013cdad-735f-49b3-945a-d33ef136102e2022-03-27T02:02:50ZPersistence of lymphocytic choriomeningitis virus at very low levels in immune mice.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a013cdad-735f-49b3-945a-d33ef136102eEnglishSymplectic Elements at Oxford1999Ciurea, AKlenerman, PHunziker, LHorvath, EOdermatt, BOchsenbein, AHengartner, HZinkernagel, RLymphocytic choriomeningitis virus (LCMV), strain WE, is a non-cytopathic RNA virus that is highly adapted to its natural host, the mouse. Acute infection of adult mice leads to generalized virus spread, followed by cytotoxic T lymphocyte-mediated virus clearance below the detection levels of conventional assays within 2-3 weeks. Indirect evidence had suggested that virus or viral antigen might persist in the immune mouse. Here we demonstrate LCMV-WE persistence at low levels after infection with 10(2) or 10(6) plaque-forming units, shown as viral genome, viral antigen, and replicative virus using sensitive in vitro and in vivo assays. The finding that LCMV-WE persists in the face of apparently intact immune responses resembles the situation in some viral (hepatitis B and C, HIV) and bacterial (tuberculosis, leprosy) infections in humans; the results are relevant to the understanding not only of other murine and human persistent viral infections but also of protective immunological memory by "infection immunity." |
| spellingShingle | Ciurea, A Klenerman, P Hunziker, L Horvath, E Odermatt, B Ochsenbein, A Hengartner, H Zinkernagel, R Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice. |
| title | Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice. |
| title_full | Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice. |
| title_fullStr | Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice. |
| title_full_unstemmed | Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice. |
| title_short | Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice. |
| title_sort | persistence of lymphocytic choriomeningitis virus at very low levels in immune mice |
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