Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

The mechanosensitive two-pore domain (K2P) K(+) channels (TREK-1, TREK-2, and TRAAK) are important for mechanical and thermal nociception. However, the mechanisms underlying their gating by membrane stretch remain controversial. Here we use molecular dynamics simulations to examine their behavior in...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Aryal, P, Jarerattanachat, V, Clausen, M, Schewe, M, McClenaghan, C, Argent, L, Conrad, L, Dong, Y, Pike, A, Carpenter, E, Baukrowitz, T, Sansom, M, Tucker, S
Format:	Journal article
Język:	English
Wydane:	Cell Press 2017

Podobne zapisy

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.
od: McClenaghan, C, i wsp.
Wydane: (2016)

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.
od: McClenaghan, C, i wsp.
Wydane: (2016)

The biophysical and structural mechanisms underlying mechanosensitivity of the TREK-2 potassium channel
od: Jarerattanachat, V
Wydane: (2018)

Asymmetric mechanosensitivity in a eukaryotic ion channel
od: Clausen, M, i wsp.
Wydane: (2017)

The effects of stretch activation on ionic selectivity of the TREK-2 K2P K(+) channel
od: Nematian-Ardestani, E, i wsp.
Wydane: (2017)

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac
od: Dong, Y, i wsp.
Wydane: (2015)

Investigations into the structure, function and pharmacology of TREK K2P potassium channels
od: McClenaghan, C
Wydane: (2015)

Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate
od: Proks, P, i wsp.
Wydane: (2021)

Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2
od: Ben Sorum, i wsp.
Wydane: (2024-04-01)

K2P and Kir K+ Channels in Physiological Bilayers
od: Schmidt, MR, i wsp.
Wydane: (2013)

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
od: Rödström, KEJ, i wsp.
Wydane: (2024)

Effects of ionic strength on gating and permeation of TREK-2 K2P channels
od: Conrad, LJ, i wsp.
Wydane: (2021)

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
od: Karin E. J. Rödström, i wsp.
Wydane: (2024-05-01)

Mechanosensitive channels: stress relief.
od: Biggin, P, i wsp.
Wydane: (2003)

Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels
od: Berke Türkaydin, i wsp.
Wydane: (2024-05-01)

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1.
od: Rapedius, M, i wsp.
Wydane: (2012)

Mechanosensitive TRPV4 channel guides maturation and organization of the bilayered mammary epithelium
od: Kärki Tytti, i wsp.
Wydane: (2024-03-01)

Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia
od: Niels Decher, i wsp.
Wydane: (2017-02-01)

Transition between conformational states of the TREK-1 K2P channel promoted by interaction with PIP2
od: Panasawatwong, A, i wsp.
Wydane: (2022)

Cholesterol regulation of mechanosensitive ion channels
od: Katie M. Beverley, i wsp.
Wydane: (2024-01-01)

A novel mechanism of voltage sensing and gating in K2P potassium channels
od: Schewe, M, i wsp.
Wydane: (2014)

A Novel Mechanism of Voltage Sensing and Gating in K2P Potassium Channels
od: Schewe, M, i wsp.
Wydane: (2014)

A novel mechanism of voltage sensing and gating in K2P potassium channels
od: Rapedius, M, i wsp.
Wydane: (2014)

Conformational rearrangements during PIP2 gating in Kir channels
od: Rapedius, M, i wsp.
Wydane: (2007)

Nanobody mediated crystallization of an archeal mechanosensitive channel
od: Moberg, Per, i wsp.
Wydane: (2014)

Incorporation of the mechanosensitive channel (MscL) and the amyloid Abeta[1-40] peptide by vesicle fusion into planar lipid bilayers
od: Mendes, G, i wsp.
Wydane: (2005)

Influence of the N terminus on the biophysical properties and pharmacology of TREK1 potassium channels.
od: Veale, E, i wsp.
Wydane: (2014)

Mechanosensitive channel activation by diffusio-osmotic force.
od: Bonthuis, D, i wsp.
Wydane: (2014)

Mechanosensitive ion channels, Part A-B /
od: Hamill, Owen P.
Wydane: (2007)

The Role of Mechanosensitive Piezo Channels in Chronic Pain
od: Wan Y, i wsp.
Wydane: (2024-12-01)

Roles of mechanosensitive ion channels in immune cells
od: Kexin Xia, i wsp.
Wydane: (2024-01-01)

Observing mechanosensitive channels in action in living bacteria
od: Mohammad Sharifian Gh., i wsp.
Wydane: (2024-03-01)

Structural and thermodynamic characterization of the gating pathway in a K+ channel
od: Bollepalli, M, i wsp.
Wydane: (2014)

Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel
od: Nematian-Ardestani, E, i wsp.
Wydane: (2019)

The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment
od: Bavat Bornstein, i wsp.
Wydane: (2024-01-01)

Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing.
od: Rapedius, M, i wsp.
Wydane: (2007)

Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels
od: Paraschiv, Alexandru, i wsp.
Wydane: (2020)

H bonding at the helix-bundle crossing controls gating in Kir potassium channels.
od: Rapedius, M, i wsp.
Wydane: (2007)

Exploring models of the influenza A M2 channel: MD simulations in a phospholipid bilayer.
od: Forrest, L, i wsp.
Wydane: (2000)

Hydrophobic gating in ion channels.
od: Aryal, P, i wsp.
Wydane: (2015)