Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

The mechanosensitive two-pore domain (K2P) K(+) channels (TREK-1, TREK-2, and TRAAK) are important for mechanical and thermal nociception. However, the mechanisms underlying their gating by membrane stretch remain controversial. Here we use molecular dynamics simulations to examine their behavior in...

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Бібліографічні деталі
Автори: Aryal, P, Jarerattanachat, V, Clausen, M, Schewe, M, McClenaghan, C, Argent, L, Conrad, L, Dong, Y, Pike, A, Carpenter, E, Baukrowitz, T, Sansom, M, Tucker, S
Формат: Journal article
Мова:English
Опубліковано: Cell Press 2017

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