The role of clearance in neurodegenerative diseases
Alzheimer’s disease, the most common form of dementia, is a systemic neurological disorder associated with the formation of toxic, pathological aggregates of proteins within the brain that lead to severe cognitive decline, and eventually, death. In normal physiological conditions, the brain rids its...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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Society for Industrial and Applied Mathematics
2023
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| _version_ | 1826313705267134464 |
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| author | Brennan, GS Thompson, TB Oliveri, H Rognes, ME Goriely, A |
| author_facet | Brennan, GS Thompson, TB Oliveri, H Rognes, ME Goriely, A |
| author_sort | Brennan, GS |
| collection | OXFORD |
| description | Alzheimer’s disease, the most common form of dementia, is a systemic neurological disorder associated with the formation of toxic, pathological aggregates of proteins within the brain that lead to severe cognitive decline, and eventually, death. In normal physiological conditions, the brain rids itself of toxic proteins using various clearance mechanisms. The efficacy of brain clearance can be adversely affected by the presence of toxic proteins and is also known to decline with age. Motivated by recent findings, such as the connection between brain cerebrospinal fluid clearance and sleep, we propose a mathematical model coupling the progression of toxic proteins over the brain’s structural network and protein clearance. The model is used to study the interplay between clearance in the brain, toxic seeding, brain network connectivity, aging, and progression in neurodegenerative diseases such as Alzheimer’s disease. Our findings provide a theoretical framework for the growing body of medical research showing that clearance plays an important role in the etiology, progression, and treatment of Alzheimer’s disease. |
| first_indexed | 2024-03-07T07:53:19Z |
| format | Journal article |
| id | oxford-uuid:a03a94b3-e028-4184-9b65-20857fd85a16 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:19:13Z |
| publishDate | 2023 |
| publisher | Society for Industrial and Applied Mathematics |
| record_format | dspace |
| spelling | oxford-uuid:a03a94b3-e028-4184-9b65-20857fd85a162024-07-26T08:49:24ZThe role of clearance in neurodegenerative diseasesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a03a94b3-e028-4184-9b65-20857fd85a16EnglishSymplectic ElementsSociety for Industrial and Applied Mathematics2023Brennan, GSThompson, TBOliveri, HRognes, MEGoriely, AAlzheimer’s disease, the most common form of dementia, is a systemic neurological disorder associated with the formation of toxic, pathological aggregates of proteins within the brain that lead to severe cognitive decline, and eventually, death. In normal physiological conditions, the brain rids itself of toxic proteins using various clearance mechanisms. The efficacy of brain clearance can be adversely affected by the presence of toxic proteins and is also known to decline with age. Motivated by recent findings, such as the connection between brain cerebrospinal fluid clearance and sleep, we propose a mathematical model coupling the progression of toxic proteins over the brain’s structural network and protein clearance. The model is used to study the interplay between clearance in the brain, toxic seeding, brain network connectivity, aging, and progression in neurodegenerative diseases such as Alzheimer’s disease. Our findings provide a theoretical framework for the growing body of medical research showing that clearance plays an important role in the etiology, progression, and treatment of Alzheimer’s disease. |
| spellingShingle | Brennan, GS Thompson, TB Oliveri, H Rognes, ME Goriely, A The role of clearance in neurodegenerative diseases |
| title | The role of clearance in neurodegenerative diseases |
| title_full | The role of clearance in neurodegenerative diseases |
| title_fullStr | The role of clearance in neurodegenerative diseases |
| title_full_unstemmed | The role of clearance in neurodegenerative diseases |
| title_short | The role of clearance in neurodegenerative diseases |
| title_sort | role of clearance in neurodegenerative diseases |
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