Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction.

Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction.

Renal cell carcinoma (RCC) infiltrating lymphocytes (TILs) express killer cell immunoglobulinlike receptors (KIRs) that inhibit the antitumor CD8(+) T-cell lysis. In the present study, to better examine the functional consequences of KIR engagement on cytotoxic T lymphocyte (CTL)/tumor interaction,...

书目详细资料
Main Authors:	Guerra, N, Michel, F, Gati, A, Gaudin, C, Mishal, Z, Escudier, B, Acuto, O, Chouaib, S, Caignard, A
格式:	Journal article
语言:	English
出版:	2002

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