Quantum capacitance as a reagentless molecular sensing element
The application of nanoscale capacitance as a transduction of molecular recognition relevant to molecular diagnostics is demonstrated. The energy-related signal relates directly to the electron occupation of quantized states present in readily fabricated molecular junctions such as those presented b...
| Prif Awduron: | , , |
|---|---|
| Fformat: | Journal article |
| Iaith: | English |
| Cyhoeddwyd: |
Royal Society of Chemistry
2017
|
| _version_ | 1826288218587267072 |
|---|---|
| author | Bueno, P Bedatty Fernandes, F Davis, J |
| author_facet | Bueno, P Bedatty Fernandes, F Davis, J |
| author_sort | Bueno, P |
| collection | OXFORD |
| description | The application of nanoscale capacitance as a transduction of molecular recognition relevant to molecular diagnostics is demonstrated. The energy-related signal relates directly to the electron occupation of quantized states present in readily fabricated molecular junctions such as those presented by redox switchable self-assembled molecular monolayers, reduced graphene oxide or redox-active graphene composite films, assembled on standard metallic or micro-fabricated electrodes. Sensor design is thus based on the response of a confined and resolved electronic density of states to target binding and the associated change in interfacial chemical potential. Demonstrated herein with a number of clinically important markers, this represents a new potent and ultrasensitive molecular detection enabling energy transducer principle capable of quantifying, in a single step and reagentless manner, markers within biological fluid. |
| first_indexed | 2024-03-07T02:10:24Z |
| format | Journal article |
| id | oxford-uuid:a0701015-ca97-4998-9eb8-cf2ccac1773b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:10:24Z |
| publishDate | 2017 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:a0701015-ca97-4998-9eb8-cf2ccac1773b2022-03-27T02:05:23ZQuantum capacitance as a reagentless molecular sensing elementJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a0701015-ca97-4998-9eb8-cf2ccac1773bEnglishSymplectic Elements at OxfordRoyal Society of Chemistry2017Bueno, PBedatty Fernandes, FDavis, JThe application of nanoscale capacitance as a transduction of molecular recognition relevant to molecular diagnostics is demonstrated. The energy-related signal relates directly to the electron occupation of quantized states present in readily fabricated molecular junctions such as those presented by redox switchable self-assembled molecular monolayers, reduced graphene oxide or redox-active graphene composite films, assembled on standard metallic or micro-fabricated electrodes. Sensor design is thus based on the response of a confined and resolved electronic density of states to target binding and the associated change in interfacial chemical potential. Demonstrated herein with a number of clinically important markers, this represents a new potent and ultrasensitive molecular detection enabling energy transducer principle capable of quantifying, in a single step and reagentless manner, markers within biological fluid. |
| spellingShingle | Bueno, P Bedatty Fernandes, F Davis, J Quantum capacitance as a reagentless molecular sensing element |
| title | Quantum capacitance as a reagentless molecular sensing element |
| title_full | Quantum capacitance as a reagentless molecular sensing element |
| title_fullStr | Quantum capacitance as a reagentless molecular sensing element |
| title_full_unstemmed | Quantum capacitance as a reagentless molecular sensing element |
| title_short | Quantum capacitance as a reagentless molecular sensing element |
| title_sort | quantum capacitance as a reagentless molecular sensing element |
| work_keys_str_mv | AT buenop quantumcapacitanceasareagentlessmolecularsensingelement AT bedattyfernandesf quantumcapacitanceasareagentlessmolecularsensingelement AT davisj quantumcapacitanceasareagentlessmolecularsensingelement |