Sequence-specific synthesis of macromolecules using DNA-templated chemistry.
Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecul...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797085564970729472 |
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| author | Milnes, P Mckee, M Bath, J Song, L Stulz, E Turberfield, A O'Reilly, R |
| author_facet | Milnes, P Mckee, M Bath, J Song, L Stulz, E Turberfield, A O'Reilly, R |
| author_sort | Milnes, P |
| collection | OXFORD |
| description | Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control. |
| first_indexed | 2024-03-07T02:10:29Z |
| format | Journal article |
| id | oxford-uuid:a0783ebd-ea90-445e-9679-a754a1998b84 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:10:29Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:a0783ebd-ea90-445e-9679-a754a1998b842022-03-27T02:05:43ZSequence-specific synthesis of macromolecules using DNA-templated chemistry.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a0783ebd-ea90-445e-9679-a754a1998b84EnglishSymplectic Elements at Oxford2012Milnes, PMckee, MBath, JSong, LStulz, ETurberfield, AO'Reilly, RUsing a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control. |
| spellingShingle | Milnes, P Mckee, M Bath, J Song, L Stulz, E Turberfield, A O'Reilly, R Sequence-specific synthesis of macromolecules using DNA-templated chemistry. |
| title | Sequence-specific synthesis of macromolecules using DNA-templated chemistry. |
| title_full | Sequence-specific synthesis of macromolecules using DNA-templated chemistry. |
| title_fullStr | Sequence-specific synthesis of macromolecules using DNA-templated chemistry. |
| title_full_unstemmed | Sequence-specific synthesis of macromolecules using DNA-templated chemistry. |
| title_short | Sequence-specific synthesis of macromolecules using DNA-templated chemistry. |
| title_sort | sequence specific synthesis of macromolecules using dna templated chemistry |
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