Generation and site-directed mutagenesis of a 35K-Fc fusion protein with increased potency of CC chemokine blockade

Generation and site-directed mutagenesis of a 35K-Fc fusion protein with increased potency of CC chemokine blockade

Manylion Llyfryddiaeth
Prif Awduron:	White, G, McNeill, E, Channon, K, Greaves, D
Fformat:	Conference item
Cyhoeddwyd:	2010

Eitemau Tebyg

Site-directed mutagenesis of the CC chemokine binding protein 35K-Fc reveals residues essential for activity and mutations that increase the potency of CC chemokine blockade.
gan: White, G, et al.
Cyhoeddwyd: (2011)

Hydrodynamic gene delivery of CC chemokine binding Fc fusion proteins to target acute vascular inflammation in vivo.
gan: McNeill, E, et al.
Cyhoeddwyd: (2015)

Expression of a membrane associated CC-chemokine inhibitor protein reduces in vitro macrophage chemotaxis to CC chemokines
gan: McNeill, E, et al.
Cyhoeddwyd: (2010)

Membrane-bound CC chemokine inhibitor 35K provides localized inhibition of CC chemokine activity in vitro and in vivo.
gan: Bursill, C, et al.
Cyhoeddwyd: (2006)

A membrane-bound vaccinia viral protein 'mem35k' blocks CC-chemokine induced cell migration and CC-chemokine activity in vitro
gan: Bursill, C, et al.
Cyhoeddwyd: (2005)

Adenoviral delivery of CC-chemokine inhibitor '35K' reduces macrophage recruitment and atherosclerosis in ApoE knockout mice
gan: Bursill, C, et al.
Cyhoeddwyd: (2004)

Adenoviral mediated delivery of a vaccinia viral protein (35K) blocks CC-chemokine activity in vitro and in vivo and may therefore be a useful therapeutic strategy to reduce the initiation and progression of CC-chemokine induced atherosclerosis
gan: Bursill, C, et al.
Cyhoeddwyd: (2003)

Adenoviral-mediated delivery of a CC-chemokine inhibitor ('35K') attenuates atherosclerotic plaque formation in apolipoprotein E-knockout mice
gan: Bursill, C, et al.
Cyhoeddwyd: (2004)

Adenoviral delivery of a Cc-chemokine inhibitor, "35k," reduces macrophage recruitment and atherosclerosis in Apoe knockout mice
gan: Bursill, C, et al.
Cyhoeddwyd: (2004)

Adenoviral mediated delivery of a CC chemokine (CK) inhibitor ("35K") attenuates atherosclerotic plaque formation in apolipoprotein E-knockout mice
gan: Bursill, C, et al.
Cyhoeddwyd: (2004)

Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis.
gan: McNeill, E, et al.
Cyhoeddwyd: (2014)

Lentiviral gene transfer to reduce atherosclerosis progression by long-term CC-chemokine inhibition.
gan: Bursill, C, et al.
Cyhoeddwyd: (2009)

Broad-spectrum CC-chemokine blockade by gene transfer inhibits macrophage recruitment and atherosclerotic plaque formation in apolipoprotein E-knockout mice.
gan: Bursill, C, et al.
Cyhoeddwyd: (2004)

Adenoviral-mediated delivery of a viral chemokine binding protein blocks CC-chemokine activity in vitro and in vivo.
gan: Bursill, C, et al.
Cyhoeddwyd: (2003)

Broad spectrum adenoviral CC-chemokine blockade attenuates long term vein graft accelerated atherosclerosis in ApoE-knockout mice
gan: Ali, Z, et al.
Cyhoeddwyd: (2007)

Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain
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Cyhoeddwyd: (2021-11-01)

CC chemokine receptors and chronic inflammation--therapeutic opportunities and pharmacological challenges.
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Chemokines, chemokine receptors and atherosclerosis
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The Downstream Regulation of Chemokine Receptor Signalling: Implications for Atherosclerosis
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Role of site-directed mutagenesis and adjuvants in the stability and potency of anthrax protective antigen
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Gene transfer of a broad spectrum CC-chemokine inhibitor reduces vein graft atherosclerosis in apolipoprotein E-knockout mice.
gan: Ali, Z, et al.
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The roles of CC chemokines in response to radiation
gan: Lei Wang, et al.
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Adenoviral gene transfer of a broad spectrum CC-chemokine inhibitor reduces vein graft atherosclerosis in apolipoprotein E-knockout mice
gan: Ali, Z, et al.
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Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter.
gan: Liddiard, K, et al.
Cyhoeddwyd: (2006)

Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter
gan: Liddiard, K, et al.
Cyhoeddwyd: (2006)

Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter
gan: Liddiard, K, et al.
Cyhoeddwyd: (2006)

YIA5 RGS-1 Regulates Leukocyte Trafficking in Atherosclerosis and Aortic Aneurysm Formation through Chemokine Receptor Desensitisation.
gan: Patel, J, et al.
Cyhoeddwyd: (2014)

Site-Directed Mutagenesis by Fusion of Contiguous DNA Fragments
gan: Sergio Carmona, et al.
Cyhoeddwyd: (1999-03-01)

Gene transfer of a broad spectrum CC-chemokine inhibitor reduces macrophage recruitment and smooth muscle content in vein graft atherosclerosis in apolipoprotein E-knockout mice
gan: Ali, Z, et al.
Cyhoeddwyd: (2005)

Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8
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Cyhoeddwyd: (2023-12-01)

CC chemokines Modulate Immune responses in Pulmonary Hypertension
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Role of CC-chemokine ligand 2 in gynecological cancer
gan: Jia-Jia Zhang, et al.
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Fractalkine promotes human monocyte survival via a reduction in oxidative stress.
gan: White, G, et al.
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CC chemokines and receptors in osteoarthritis: new insights and potential targets
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Cyhoeddwyd: (2023-07-01)

Fractalkine: one chemokine, many functions.
gan: White, G, et al.
Cyhoeddwyd: (2009)

Enhanced potency of immunotherapy against B‐cell precursor acute lymphoblastic leukemia by combination of an Fc‐engineered CD19 antibody and CD47 blockade
gan: Denis M. Schewe, et al.
Cyhoeddwyd: (2024-02-01)

The role of chemokines in atherosclerosis: recent evidence from experimental models and population genetics.
gan: Bursill, C, et al.
Cyhoeddwyd: (2004)

CC chemokine receptor 7 promotes macrophage recruitment and induces M2-polarization through CC chemokine ligand 19&21 in oral squamous cell carcinoma
gan: Wan-Hang Zhou, et al.
Cyhoeddwyd: (2022-07-01)

Single cell transcriptomics reveals how hyperlipidaemia alters monocyte/macrophage differentiation at sites of inflammation
gan: Purvis, G, et al.
Cyhoeddwyd: (2020)

Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications.
gan: McNeill, E, et al.
Cyhoeddwyd: (2010)