Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.

Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway inhibition. Here we show that the lack of MITF is associated with more severe resistance to a range of inhibitors, while its presence is required for r...

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Bibliographic Details
Main Authors: Müller, J, Krijgsman, O, Tsoi, J, Robert, L, Hugo, W, Song, C, Kong, X, Possik, P, Cornelissen-Steijger, P, Foppen, M, Kemper, K, Goding, C, McDermott, U, Blank, C, Haanen, J, Graeber, T, Ribas, A, Lo, R, Peeper, D
Format: Journal article
Language:English
Published: 2014

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