Experimental and clinical possibilities of MR spectroscopy of the heart
MR-spectroscopy of the heart is a relatively new technique for the study of various aspects of cardiac metabolism. The majority of results has so far been obtained with the isolated perfused heart. Here, 31P-MR spectroscopy can be employed to measure high-energy phosphate metabolism and intracellula...
| मुख्य लेखकों: | , , , , , , |
|---|---|
| स्वरूप: | Journal article |
| भाषा: | German |
| प्रकाशित: |
1991
|
| _version_ | 1826288242259918848 |
|---|---|
| author | Neubauer, S Ertl, G Krahe, T Schindler, R Hillenbrand, H Lackner, K Kochsiek, K |
| author_facet | Neubauer, S Ertl, G Krahe, T Schindler, R Hillenbrand, H Lackner, K Kochsiek, K |
| author_sort | Neubauer, S |
| collection | OXFORD |
| description | MR-spectroscopy of the heart is a relatively new technique for the study of various aspects of cardiac metabolism. The majority of results has so far been obtained with the isolated perfused heart. Here, 31P-MR spectroscopy can be employed to measure high-energy phosphate metabolism and intracellular pH repeatedly and non-invasively. Using a technique called saturation transfer, velocities of enzymatic reactions, such as the creatine kinase reaction, can be measured. Intra- and extracellular Na+ and K+ concentrations can be registered with 23Na- and 39K-MR in conjunction with shift reagent. 13C-MR can be used to tackle carbohydrate metabolism. In-situ-R-spectroscopy allows determination of high-energy phosphates in intact large mammals. Clinical applications of MR-spectroscopy remain to be defined; preliminary results indicate high diagnostic and prognostic potential for patients with coronary artery disease and congestive heart failure. |
| first_indexed | 2024-03-07T02:10:45Z |
| format | Journal article |
| id | oxford-uuid:a08d4a9f-6a26-4b64-b647-827d66d253d3 |
| institution | University of Oxford |
| language | German |
| last_indexed | 2024-03-07T02:10:45Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:a08d4a9f-6a26-4b64-b647-827d66d253d32022-03-27T02:06:22ZExperimental and clinical possibilities of MR spectroscopy of the heartJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a08d4a9f-6a26-4b64-b647-827d66d253d3GermanSymplectic Elements at Oxford1991Neubauer, SErtl, GKrahe, TSchindler, RHillenbrand, HLackner, KKochsiek, KMR-spectroscopy of the heart is a relatively new technique for the study of various aspects of cardiac metabolism. The majority of results has so far been obtained with the isolated perfused heart. Here, 31P-MR spectroscopy can be employed to measure high-energy phosphate metabolism and intracellular pH repeatedly and non-invasively. Using a technique called saturation transfer, velocities of enzymatic reactions, such as the creatine kinase reaction, can be measured. Intra- and extracellular Na+ and K+ concentrations can be registered with 23Na- and 39K-MR in conjunction with shift reagent. 13C-MR can be used to tackle carbohydrate metabolism. In-situ-R-spectroscopy allows determination of high-energy phosphates in intact large mammals. Clinical applications of MR-spectroscopy remain to be defined; preliminary results indicate high diagnostic and prognostic potential for patients with coronary artery disease and congestive heart failure. |
| spellingShingle | Neubauer, S Ertl, G Krahe, T Schindler, R Hillenbrand, H Lackner, K Kochsiek, K Experimental and clinical possibilities of MR spectroscopy of the heart |
| title | Experimental and clinical possibilities of MR spectroscopy of the heart |
| title_full | Experimental and clinical possibilities of MR spectroscopy of the heart |
| title_fullStr | Experimental and clinical possibilities of MR spectroscopy of the heart |
| title_full_unstemmed | Experimental and clinical possibilities of MR spectroscopy of the heart |
| title_short | Experimental and clinical possibilities of MR spectroscopy of the heart |
| title_sort | experimental and clinical possibilities of mr spectroscopy of the heart |
| work_keys_str_mv | AT neubauers experimentalandclinicalpossibilitiesofmrspectroscopyoftheheart AT ertlg experimentalandclinicalpossibilitiesofmrspectroscopyoftheheart AT krahet experimentalandclinicalpossibilitiesofmrspectroscopyoftheheart AT schindlerr experimentalandclinicalpossibilitiesofmrspectroscopyoftheheart AT hillenbrandh experimentalandclinicalpossibilitiesofmrspectroscopyoftheheart AT lacknerk experimentalandclinicalpossibilitiesofmrspectroscopyoftheheart AT kochsiekk experimentalandclinicalpossibilitiesofmrspectroscopyoftheheart |