E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit.

E2F activity is negatively regulated by retinoblastoma protein (pRb) through binding to the E2F-1 subunit. Within the E2F heterodimer, DP proteins are E2F partner subunits that allow proper cell cycle progression. In contrast to the other DP proteins, the newest member of the family, DP-4, downregul...

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Bibliografische gegevens
Hoofdauteurs: Ingram, L, Munro, S, Coutts, A, La Thangue, N
Formaat: Journal article
Taal:English
Gepubliceerd in: 2011