Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis.
Presence of early secretory antigenic target-6 (ESAT-6)-specific, interferon- gamma -secreting T cells in blood accurately marks tuberculosis infection. In tuberculous pleural effusions from 10 patients with tuberculosis, these cells were concentrated a mean of 15-fold (standard deviation, +/-6-fold...
| Auteurs principaux: | , , , , , , , , , |
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| Format: | Conference item |
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2005
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| _version_ | 1826288257167523840 |
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| author | Wilkinson, K Wilkinson, R Pathan, A Ewer, K Prakash, M Klenerman, P Maskell, N Davies, R Pasvol, G Lalvani, A |
| author_facet | Wilkinson, K Wilkinson, R Pathan, A Ewer, K Prakash, M Klenerman, P Maskell, N Davies, R Pasvol, G Lalvani, A |
| author_sort | Wilkinson, K |
| collection | OXFORD |
| description | Presence of early secretory antigenic target-6 (ESAT-6)-specific, interferon- gamma -secreting T cells in blood accurately marks tuberculosis infection. In tuberculous pleural effusions from 10 patients with tuberculosis, these cells were concentrated a mean of 15-fold (standard deviation, +/-6-fold), relative to their level in peripheral blood (P=.014), and displayed rapid effector function. Such cells were absent in 8 control patients with nontuberculous pleural disease. The recruitment of ESAT-6-specific T cells to inflamed tuberculous tissue demonstrates their function in vivo and suggests a novel way to diagnose tuberculous pleuritis. |
| first_indexed | 2024-03-07T02:10:59Z |
| format | Conference item |
| id | oxford-uuid:a0a112d7-a0e5-4f18-9bae-862d9f3bd4b8 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:10:59Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:a0a112d7-a0e5-4f18-9bae-862d9f3bd4b82022-03-27T02:06:51ZEx vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis.Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:a0a112d7-a0e5-4f18-9bae-862d9f3bd4b8Symplectic Elements at Oxford2005Wilkinson, KWilkinson, RPathan, AEwer, KPrakash, MKlenerman, PMaskell, NDavies, RPasvol, GLalvani, APresence of early secretory antigenic target-6 (ESAT-6)-specific, interferon- gamma -secreting T cells in blood accurately marks tuberculosis infection. In tuberculous pleural effusions from 10 patients with tuberculosis, these cells were concentrated a mean of 15-fold (standard deviation, +/-6-fold), relative to their level in peripheral blood (P=.014), and displayed rapid effector function. Such cells were absent in 8 control patients with nontuberculous pleural disease. The recruitment of ESAT-6-specific T cells to inflamed tuberculous tissue demonstrates their function in vivo and suggests a novel way to diagnose tuberculous pleuritis. |
| spellingShingle | Wilkinson, K Wilkinson, R Pathan, A Ewer, K Prakash, M Klenerman, P Maskell, N Davies, R Pasvol, G Lalvani, A Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis. |
| title | Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis. |
| title_full | Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis. |
| title_fullStr | Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis. |
| title_full_unstemmed | Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis. |
| title_short | Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis. |
| title_sort | ex vivo characterization of early secretory antigenic target 6 specific t cells at sites of active disease in pleural tuberculosis |
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