Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.

Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.

Show other versions (1)

Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinases (DYRKs) play key roles in brain development, regulation of splicing, and apoptosis, and are potential drug targets for neurodegenerative diseases and cancer. We present crystal structures of one representative member of each DYRK subfam...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Soundararajan, M, Roos, A, Savitsky, P, Filippakopoulos, P, Kettenbach, A, Olsen, J, Gerber, SA, Eswaran, J, Knapp, S, Elkins, J
Format:	Journal article
Sprog:	English
Udgivet:	2013

Lignende værker

Structures of down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition
af: Soundararajan, M, et al.
Udgivet: (2013)

Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases.
af: Myrianthopoulos, V, et al.
Udgivet: (2013)

Rapid determination of multiple linear kinase substrate motifs by mass spectrometry.
af: Kettenbach, A, et al.
Udgivet: (2012)

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.
af: Filippakopoulos, P, et al.
Udgivet: (2008)

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.
af: Filippakopoulos, P, et al.
Udgivet: (2008)

UnPAKing the class differences among p21-activated kinases.
af: Eswaran, J, et al.
Udgivet: (2008)

Structure and functional characterization of the atypical human kinase haspin.
af: Eswaran, J, et al.
Udgivet: (2009)

Structure and functional characterization of the atypical human kinase haspin.
af: Eswaran, J, et al.
Udgivet: (2009)

Differential regulation of expression of the protein kinases DYRK1A and DYRK1B in cancer cells
af: Vincent Andreas Vorwerk, et al.
Udgivet: (2024-10-01)

Leucettines, a family of pharmacological inhibitors of DYRKs and CLKs kinases derived from the marine sponge Leucettamine B
af: Tahtouh, T, et al.
Udgivet: (2012)

SH2 domains: modulators of nonreceptor tyrosine kinase activity.
af: Filippakopoulos, P, et al.
Udgivet: (2009)

Insights into protein kinase regulation and inhibition by large scale structural comparison.
af: Eswaran, J, et al.
Udgivet: (2010)

Mirk/Dyrk1B Kinase Inhibitors in Targeted Cancer Therapy
af: Nikolaos Kokkorakis, et al.
Udgivet: (2024-04-01)

Structure and substrate specificity of the Pim-1 kinase
af: Bullock, A, et al.
Udgivet: (2005)

Structure and substrate specificity of the Pim-1 kinase.
af: Bullock, A, et al.
Udgivet: (2005)

Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs
af: Eswaran, J, et al.
Udgivet: (2007)

Insights from the protein interaction Universe of the multifunctional “Goldilocks” kinase DYRK1A
af: Varsha Ananthapadmanabhan, et al.
Udgivet: (2023-10-01)

Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs.
af: Eswaran, J, et al.
Udgivet: (2007)

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells
af: Bernard Khor, et al.
Udgivet: (2015-05-01)

Selective inhibition of the kinase DYRK1A by targeting its folding process
af: Isao Kii, et al.
Udgivet: (2016-04-01)

Identification of the Kinase-Substrate Recognition Interface between MYPT1 and Rho-Kinase
af: Mutsuki Amano, et al.
Udgivet: (2022-01-01)

Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors.
af: Akué-Gédu, R, et al.
Udgivet: (2009)

Structure of dystrophia myotonica protein kinase.
af: Elkins, J, et al.
Udgivet: (2009)

Structure of dystrophia myotonica protein kinase.
af: Elkins, J, et al.
Udgivet: (2009)

DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.
af: Christophe Noll, et al.
Udgivet: (2009-10-01)

Crystal Structure of Sphingosine Kinase 1 with PF-543.
af: Wang, J, et al.
Udgivet: (2014)

Dual specificity kinase DYRK3 regulates cell migration by influencing the stability of protrusions
af: Martina Ramella, et al.
Udgivet: (2024-04-01)

An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei
af: Mathieu Cayla, et al.
Udgivet: (2020-03-01)

DYRK1A Kinase Inhibitors Promote β-Cell Survival and Insulin Homeostasis
af: Agata Barzowska, et al.
Udgivet: (2021-08-01)

Fragment screening of cyclin G-associated kinase by weak affinity chromatography.
af: Meiby, E, et al.
Udgivet: (2012)

Fragment screening of cyclin G-associated kinase by weak affinity chromatography
af: Meiby, E, et al.
Udgivet: (2012)

Evolution of protein kinase substrate recognition at the active site.
af: David Bradley, et al.
Udgivet: (2019-06-01)

Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging
af: Norman van Rhijn, et al.
Udgivet: (2024-06-01)

Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture.
af: Eswaran, J, et al.
Udgivet: (2008)

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
af: Tahtouh, T, et al.
Udgivet: (2012)

DYRK-family kinases regulate Candida albicans morphogenesis and virulence through the Ras1/PKA pathway
af: Jessie MacAlpine, et al.
Udgivet: (2023-12-01)

Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors.
af: Katharina Rüben, et al.
Udgivet: (2015-01-01)

High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.
af: Miduturu, C, et al.
Udgivet: (2011)

Analysis of conditions affecting auto-phosphorylation of human kinases during expression in bacteria.
af: Shrestha, A, et al.
Udgivet: (2012)

Electrostatically Enhanced Association of a Pim Kinase Substrate Revealed by Stochastic Detection
af: Harrington, L, et al.
Udgivet: (2014)