Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.

Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.

Бусад хувилбаруудыг харуулах (1)

Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinases (DYRKs) play key roles in brain development, regulation of splicing, and apoptosis, and are potential drug targets for neurodegenerative diseases and cancer. We present crystal structures of one representative member of each DYRK subfam...

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Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Soundararajan, M, Roos, A, Savitsky, P, Filippakopoulos, P, Kettenbach, A, Olsen, J, Gerber, SA, Eswaran, J, Knapp, S, Elkins, J
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2013

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