Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.

Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinases (DYRKs) play key roles in brain development, regulation of splicing, and apoptosis, and are potential drug targets for neurodegenerative diseases and cancer. We present crystal structures of one representative member of each DYRK subfam...

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Váldodahkkit:	Soundararajan, M, Roos, A, Savitsky, P, Filippakopoulos, P, Kettenbach, A, Olsen, J, Gerber, SA, Eswaran, J, Knapp, S, Elkins, J
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2013

Structures of down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition Dahkki Soundararajan, M, Roos, A, Savitsky, P, Filippakopoulos, P, Eswaran, J, Knapp, S, Elkins, J, Kettenbach, A, Gerber, SA, Olsen, J

Almmustuhtton 2013

Journal article

Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.

Structures of down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition Dahkki Soundararajan, M, Roos, A, Savitsky, P, Filippakopoulos, P, Eswaran, J, Knapp, S, Elkins, J, Kettenbach, A, Gerber, SA, Olsen, J

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