Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma
<p style="text-align:justify;">Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,9...
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| Format: | Journal article |
| Language: | English |
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Springer Nature
2012
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| _version_ | 1797085654789652480 |
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| author | Vithana, E Khor, C Qiao, C Nongpiur, M George, R Chen, L Do, T Abu-Amero, K Huang, C Low, S Tajudin, L Perera, S Cheng, C Xu, L Jia, H Ho, C Sim, K Wu, R Tham, C Chew, P Su, D Oen, F Sarangapani, S Soumittra, N Osman, E Wong, H Tang, G Fan, S Meng, H Huong, D Wang, H Feng, B Baskaran, M Shantha, B Ramprasad, V Kumaramanickavel, G Iyengar, S How, A Lee, K Sivakumaran, T Yong, V Ting, S Li, Y Wang, Y Tay, W Sim, X Lavanya, R Cornes, B Zheng, Y Wong, T Loon, S Yong, V Waseem, N Yaakub, A Chia, K Allingham, R Hauser, M Lam, D Hibberd, M Bhattacharya, S Zhang, M Teo, Y Tan, D Jonas, J Tai, E Saw, S Hon, D Al-Obeidan, S Liu, J Chau, T Simmons, C Bei, J Zeng, Y Foster, P Vijaya, L Wong, T Pang, C Wang, N Aung, T |
| author_facet | Vithana, E Khor, C Qiao, C Nongpiur, M George, R Chen, L Do, T Abu-Amero, K Huang, C Low, S Tajudin, L Perera, S Cheng, C Xu, L Jia, H Ho, C Sim, K Wu, R Tham, C Chew, P Su, D Oen, F Sarangapani, S Soumittra, N Osman, E Wong, H Tang, G Fan, S Meng, H Huong, D Wang, H Feng, B Baskaran, M Shantha, B Ramprasad, V Kumaramanickavel, G Iyengar, S How, A Lee, K Sivakumaran, T Yong, V Ting, S Li, Y Wang, Y Tay, W Sim, X Lavanya, R Cornes, B Zheng, Y Wong, T Loon, S Yong, V Waseem, N Yaakub, A Chia, K Allingham, R Hauser, M Lam, D Hibberd, M Bhattacharya, S Zhang, M Teo, Y Tan, D Jonas, J Tai, E Saw, S Hon, D Al-Obeidan, S Liu, J Chau, T Simmons, C Bei, J Zeng, Y Foster, P Vijaya, L Wong, T Pang, C Wang, N Aung, T |
| author_sort | Vithana, E |
| collection | OXFORD |
| description | <p style="text-align:justify;">Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10−12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10−10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10−9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG. </p> |
| first_indexed | 2024-03-07T02:11:33Z |
| format | Journal article |
| id | oxford-uuid:a0d1fcf2-82ae-4156-9060-abd722a9c8d2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:11:33Z |
| publishDate | 2012 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:a0d1fcf2-82ae-4156-9060-abd722a9c8d22022-03-27T02:08:34ZGenome-wide association analyses identify three new susceptibility loci for primary angle closure glaucomaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a0d1fcf2-82ae-4156-9060-abd722a9c8d2EnglishSymplectic Elements at OxfordSpringer Nature2012Vithana, EKhor, CQiao, CNongpiur, MGeorge, RChen, LDo, TAbu-Amero, KHuang, CLow, STajudin, LPerera, SCheng, CXu, LJia, HHo, CSim, KWu, RTham, CChew, PSu, DOen, FSarangapani, SSoumittra, NOsman, EWong, HTang, GFan, SMeng, HHuong, DWang, HFeng, BBaskaran, MShantha, BRamprasad, VKumaramanickavel, GIyengar, SHow, ALee, KSivakumaran, TYong, VTing, SLi, YWang, YTay, WSim, XLavanya, RCornes, BZheng, YWong, TLoon, SYong, VWaseem, NYaakub, AChia, KAllingham, RHauser, MLam, DHibberd, MBhattacharya, SZhang, MTeo, YTan, DJonas, JTai, ESaw, SHon, DAl-Obeidan, SLiu, JChau, TSimmons, CBei, JZeng, YFoster, PVijaya, LWong, TPang, CWang, NAung, T <p style="text-align:justify;">Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10−12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10−10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10−9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG. </p> |
| spellingShingle | Vithana, E Khor, C Qiao, C Nongpiur, M George, R Chen, L Do, T Abu-Amero, K Huang, C Low, S Tajudin, L Perera, S Cheng, C Xu, L Jia, H Ho, C Sim, K Wu, R Tham, C Chew, P Su, D Oen, F Sarangapani, S Soumittra, N Osman, E Wong, H Tang, G Fan, S Meng, H Huong, D Wang, H Feng, B Baskaran, M Shantha, B Ramprasad, V Kumaramanickavel, G Iyengar, S How, A Lee, K Sivakumaran, T Yong, V Ting, S Li, Y Wang, Y Tay, W Sim, X Lavanya, R Cornes, B Zheng, Y Wong, T Loon, S Yong, V Waseem, N Yaakub, A Chia, K Allingham, R Hauser, M Lam, D Hibberd, M Bhattacharya, S Zhang, M Teo, Y Tan, D Jonas, J Tai, E Saw, S Hon, D Al-Obeidan, S Liu, J Chau, T Simmons, C Bei, J Zeng, Y Foster, P Vijaya, L Wong, T Pang, C Wang, N Aung, T Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma |
| title | Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma |
| title_full | Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma |
| title_fullStr | Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma |
| title_full_unstemmed | Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma |
| title_short | Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma |
| title_sort | genome wide association analyses identify three new susceptibility loci for primary angle closure glaucoma |
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