Emerging coxsackievirus A6 causing hand, foot and mouth disease, Vietnam

Emerging coxsackievirus A6 causing hand, foot and mouth disease, Vietnam

Hand, foot and mouth disease (HFMD) is a major public health issue in Asia and has global pandemic potential. Coxsackievirus A6 (CV-A6) was detected in 514/2,230 (23%) of HFMD patients admitted to 3 major hospitals in southern Vietnam during 2011–2015. Of these patients, 93 (18%) had severe HFMD. Ph...

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Bibliographic Details
Main Authors: Anh, N, Nhu, L, Van, H, Hong, N, Thanh, T, Hang, V, Ny, N, Nguyet, L, Phuong, T, Nhan, L, Hung, N, Khanh, T, Tuan, H, Viet, H, Nam, N, Viet, D, Qui, P, Wills, B, Sabanathan, S, Chau, N, Thwaites, L, Rogier van Doorn, H, Thwaites, G, Rabaa, M, Van Tan, L
Format: Journal article
Language:English
Published: Centers for Disease Control and Prevention 2018
Description
Summary:Hand, foot and mouth disease (HFMD) is a major public health issue in Asia and has global pandemic potential. Coxsackievirus A6 (CV-A6) was detected in 514/2,230 (23%) of HFMD patients admitted to 3 major hospitals in southern Vietnam during 2011–2015. Of these patients, 93 (18%) had severe HFMD. Phylogenetic analysis of 98 genome sequences revealed they belonged to cluster A and had been circulating in Vietnam for 2 years before emergence. CV-A6 movement among localities within Vietnam occurred frequently, whereas viral movement across international borders appeared rare. Skyline plots identified fluctuations in the relative genetic diversity of CV-A6 corresponding to large CV-A6–associated HFMD outbreaks worldwide. These data show that CV-A6 is an emerging pathogen and emphasize the necessity of active surveillance and understanding the mechanisms that shape the pathogen evolution and emergence, which is essential for development and implementation of intervention strategies.

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