Elimination of retroviral infectivity by N-ethylmaleimide with preservation of functional envelope glycoproteins.

Elimination of retroviral infectivity by N-ethylmaleimide with preservation of functional envelope glycoproteins.

The zinc finger motifs in retroviral nucleocapsid (NC) proteins are essential for viral replication. Disruption of these Cys-X2-Cys-X4-His-X4-Cys zinc-binding structures eliminates infectivity. To determine if N-ethylmaleimide (NEM) can inactivate human immunodeficiency virus type 1 (HIV-1) or simia...

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Bibliographic Details
Main Authors: Morcock, DR, Thomas, J, Gagliardi, T, Gorelick, R, Roser, J, Chertova, E, Bess, J, Ott, D, Sattentau, Q, Frank, I, Pope, M, Lifson, J, Henderson, L, Crise, B
Format: Journal article
Language:English
Published: 2005

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