Elimination of retroviral infectivity by N-ethylmaleimide with preservation of functional envelope glycoproteins.
The zinc finger motifs in retroviral nucleocapsid (NC) proteins are essential for viral replication. Disruption of these Cys-X2-Cys-X4-His-X4-Cys zinc-binding structures eliminates infectivity. To determine if N-ethylmaleimide (NEM) can inactivate human immunodeficiency virus type 1 (HIV-1) or simia...
Glavni autori: | Morcock, DR, Thomas, J, Gagliardi, T, Gorelick, R, Roser, J, Chertova, E, Bess, J, Ott, D, Sattentau, Q, Frank, I, Pope, M, Lifson, J, Henderson, L, Crise, B |
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Format: | Journal article |
Jezik: | English |
Izdano: |
2005
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