Yolk sac cell atlas reveals multiorgan functions during human early development
The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconception weeks by integrating single-cell protein and gene expr...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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American Association for the Advancement of Science
2023
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| _version_ | 1797112388933124096 |
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| author | Goh, I Botting, RA Rose, A Webb, S Engelbert, J Gitton, Y Stephenson, E Quiroga Londoño, M Mather, M Mende, N Imaz-Rosshandler, I Yang, L Horsfall, D Basurto-Lozada, D Chipampe, N-J Rook, V Lee, JTH Ton, M-L Keitley, D Mazin, P Vijayabaskar, MS Hannah, R Gambardella, L Green, K Ballereau, S Inoue, M Tuck, E Lorenzi, V Kwakwa, K Alsinet, C Olabi, B Miah, M Admane, C Popescu, D-M Acres, M Dixon, D Ness, T Coulthard, R Lisgo, S Henderson, DJ Dann, E Suo, C Kinston, SJ Park, J-E Polanski, K Marioni, J van Dongen, S Meyer, KB de Bruijn, M Palis, J Roberts, I |
| author_facet | Goh, I Botting, RA Rose, A Webb, S Engelbert, J Gitton, Y Stephenson, E Quiroga Londoño, M Mather, M Mende, N Imaz-Rosshandler, I Yang, L Horsfall, D Basurto-Lozada, D Chipampe, N-J Rook, V Lee, JTH Ton, M-L Keitley, D Mazin, P Vijayabaskar, MS Hannah, R Gambardella, L Green, K Ballereau, S Inoue, M Tuck, E Lorenzi, V Kwakwa, K Alsinet, C Olabi, B Miah, M Admane, C Popescu, D-M Acres, M Dixon, D Ness, T Coulthard, R Lisgo, S Henderson, DJ Dann, E Suo, C Kinston, SJ Park, J-E Polanski, K Marioni, J van Dongen, S Meyer, KB de Bruijn, M Palis, J Roberts, I |
| author_sort | Goh, I |
| collection | OXFORD |
| description | The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconception weeks by integrating single-cell protein and gene expression data. Beyond its recognized role as a site of hematopoiesis, we highlight roles in metabolism, coagulation, vascular development, and hematopoietic regulation. We reconstructed the emergence and decline of YS hematopoietic stem and progenitor cells from hemogenic endothelium and revealed a YS-specific accelerated route to macrophage production that seeds developing organs. The multiorgan functions of the YS are superseded as intraembryonic organs develop, effecting a multifaceted relay of vital functions as pregnancy proceeds. |
| first_indexed | 2024-03-07T08:23:31Z |
| format | Journal article |
| id | oxford-uuid:a0f37993-3103-4038-8c79-9b2e5b4b645f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:23:31Z |
| publishDate | 2023 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:a0f37993-3103-4038-8c79-9b2e5b4b645f2024-02-06T11:11:19ZYolk sac cell atlas reveals multiorgan functions during human early developmentJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a0f37993-3103-4038-8c79-9b2e5b4b645fEnglishSymplectic ElementsAmerican Association for the Advancement of Science2023Goh, IBotting, RARose, AWebb, SEngelbert, JGitton, YStephenson, EQuiroga Londoño, MMather, MMende, NImaz-Rosshandler, IYang, LHorsfall, DBasurto-Lozada, DChipampe, N-JRook, VLee, JTHTon, M-LKeitley, DMazin, PVijayabaskar, MSHannah, RGambardella, LGreen, KBallereau, SInoue, MTuck, ELorenzi, VKwakwa, KAlsinet, COlabi, BMiah, MAdmane, CPopescu, D-MAcres, MDixon, DNess, TCoulthard, RLisgo, SHenderson, DJDann, ESuo, CKinston, SJPark, J-EPolanski, KMarioni, Jvan Dongen, SMeyer, KBde Bruijn, MPalis, JRoberts, IThe extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconception weeks by integrating single-cell protein and gene expression data. Beyond its recognized role as a site of hematopoiesis, we highlight roles in metabolism, coagulation, vascular development, and hematopoietic regulation. We reconstructed the emergence and decline of YS hematopoietic stem and progenitor cells from hemogenic endothelium and revealed a YS-specific accelerated route to macrophage production that seeds developing organs. The multiorgan functions of the YS are superseded as intraembryonic organs develop, effecting a multifaceted relay of vital functions as pregnancy proceeds. |
| spellingShingle | Goh, I Botting, RA Rose, A Webb, S Engelbert, J Gitton, Y Stephenson, E Quiroga Londoño, M Mather, M Mende, N Imaz-Rosshandler, I Yang, L Horsfall, D Basurto-Lozada, D Chipampe, N-J Rook, V Lee, JTH Ton, M-L Keitley, D Mazin, P Vijayabaskar, MS Hannah, R Gambardella, L Green, K Ballereau, S Inoue, M Tuck, E Lorenzi, V Kwakwa, K Alsinet, C Olabi, B Miah, M Admane, C Popescu, D-M Acres, M Dixon, D Ness, T Coulthard, R Lisgo, S Henderson, DJ Dann, E Suo, C Kinston, SJ Park, J-E Polanski, K Marioni, J van Dongen, S Meyer, KB de Bruijn, M Palis, J Roberts, I Yolk sac cell atlas reveals multiorgan functions during human early development |
| title | Yolk sac cell atlas reveals multiorgan functions during human early development |
| title_full | Yolk sac cell atlas reveals multiorgan functions during human early development |
| title_fullStr | Yolk sac cell atlas reveals multiorgan functions during human early development |
| title_full_unstemmed | Yolk sac cell atlas reveals multiorgan functions during human early development |
| title_short | Yolk sac cell atlas reveals multiorgan functions during human early development |
| title_sort | yolk sac cell atlas reveals multiorgan functions during human early development |
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