The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.

Farnesyl pyrophosphate synthase (FPPS) is the major molecular target of nitrogen-containing bisphosphonates (N-BPs), used clinically as bone resorption inhibitors. We investigated the role of threonine 201 (Thr201) and tyrosine 204 (Tyr204) residues in substrate binding, catalysis and inhibition by...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Tsoumpra, M, Muniz, JR, Barnett, B, Kwaasi, A, Pilka, E, Kavanagh, K, Evdokimov, A, Walter, R, Von Delft, F, Ebetino, F, Oppermann, U, Russell, G, Dunford, J
Format: Journal article
Język:English
Wydane: 2015