An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1.

Hv1 voltage-gated proton channels mediate rapid and selective transmembrane H(+) flux and are gated by both voltage and pH gradients. Selective H(+) transfer in membrane proteins is commonly achieved by Grotthuss proton 'hopping' in chains of ionizable amino acid side chains and intraprote...

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Bibliographic Details
Main Authors: Ramsey, I, Mokrab, Y, Carvacho, I, Sands, Z, Sansom, M, Clapham, D
Format: Journal article
Language:English
Published: 2010