Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin

Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin

Hypoxia‐inducible factor (HIF) is the major transcriptional regulator of cellular responses to hypoxia. The two principal HIF‐α isoforms, HIF‐1α and HIF‐2α, are progressively stabilized in response to hypoxia and form heterodimers with HIF‐1β to activate a broad range of transcriptional responses. H...

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Bibliographic Details
Main Authors: Smythies, J, Sun, M, Masson, N, Salama, R, Simpson, P, Murray, E, Neumann, V, Cockman, M, Choudhry, H, Ratcliffe, P, Mole, D
Format: Journal article
Published: EMBO Press 2018

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