Utility of pre-operative haemoglobin concentration to guide peri-operative blood tests for hip and knee arthroplasty: a decision curve analysis

<strong>Objective<br></strong> Assess the prognostic value of pre-operative haemoglobin concentration (Hb) for identifying patients who develop severe post-operative anaemia or require blood transfusion following primary total hip or knee, or unicompartmental knee arthroplasty (THA...

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Bibliographic Details
Main Authors: Dhiman, P, Gibbs, VN, Collins, GS, Van Calster, B, Bakhishli, G, Grammatopoulos, G, Price, AJ, Taylor, A, Murphy, MF, Kendrick, BJL, Palmer, AJR
Format: Journal article
Language:English
Published: Wiley 2022
Description
Summary:<strong>Objective<br></strong> Assess the prognostic value of pre-operative haemoglobin concentration (Hb) for identifying patients who develop severe post-operative anaemia or require blood transfusion following primary total hip or knee, or unicompartmental knee arthroplasty (THA, TKA, UKA). <br><strong> Background<br></strong> Pre-operative group and save (G&S), and post-operative Hb measurement may be unnecessary for many patients undergoing hip and knee arthroplasty provided individuals at greatest risk of severe post-operative anaemia can be identified. <br><strong> Methods and Materials<br></strong> Patients undergoing THA, TKA, or UKA between 2011 and 2018 were included. Outcomes were post-operative Hb below 70 and 80 g/L, and peri-operative blood transfusion. Logistic regression assessed the association between pre-operative Hb and each outcome. Decision curve analysis compared strategies for selecting patients for G&S and post-operative Hb measurement. <br><strong> Results<br></strong> 10 015 THA, TKA and UKA procedures were performed in 8582 patients. The incidence of blood transfusion (4.5%) decreased during the study. Using procedure specific Hb thresholds to select patients for pre-operative G&S and post-operative Hb testing had a greater net benefit than selecting all patients, no patients, or patients with pre-operative anaemia. <br><strong> Conclusions<br></strong> Pre-operative G&S and post-operative Hb measurement may not be indicated for UKA or TKA when adopting restrictive transfusion thresholds, provided clinicians accept a 0.1% risk of patients developing severe undiagnosed post-operative anaemia (Hb < 70 g/L). The decision to perform these blood tests for THA patients should be based on local institutional data and selection of acceptable risk thresholds.