Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo.

Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo.

Apomine, a novel 1,1 bisphosphonate ester, increases the rate of degradation of HMG-CoA reductase, inhibiting the mevalonate pathway and thereby blocking cholesterol biosynthesis. We have investigated whether Apomine can induce myeloma cell apoptosis in vitro and modulate myeloma disease in vivo. Ap...

Podrobná bibliografie
Hlavní autoři:	Edwards, C, Mueller, G, Roelofs, A, Chantry, A, Perry, M, Russell, R, Van Camp, B, Guyon-Gellin, Y, Niesor, E, Bentzen, C, Vanderkerken, K, Croucher, P
Médium:	Journal article
Jazyk:	English
Vydáno:	2007

Podobné jednotky

Apomine, an inhibitor of HMG-COA-reductase, does not act by inhibiting protein prenylation in human myeloma cells in vitro
Autor: Roelofs, A, a další
Vydáno: (2005)

APOMINE (TM), a novel inhibitor of the meyalonate/isoprenoid pathway, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of the myeloma disease in vivo.
Autor: Croucher, P, a další
Vydáno: (2002)

Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Autor: Roelofs, A, a další
Vydáno: (2007)

Novel insights into the anti-tumour mechanism of action of apomine and its synergistic interaction with lovastatin in myeloma cells in vitro
Autor: Roelofs, A, a další
Vydáno: (2006)

Bisphosphonates and osteoprotegerin as inhibitors of myeloma bone disease.
Autor: Croucher, P, a další
Vydáno: (2003)

HMG CoA reductase inhibitors in the treatment of hypercholesterolaemias.
Autor: Aronson, J, a další
Vydáno: (1990)

Pleiotropic effects of the HMG-CoA reductase inhibitors
Autor: Mihos CG, a další
Vydáno: (2011-04-01)

Regulation of HMG-CoA reductase activity in plants.
Autor: B A Stermer, a další
Vydáno: (1994-07-01)

Activation of HMG-CoA reductase by microsomal phosphatase
Autor: K R Feingold, a další
Vydáno: (1983-03-01)

HMG-CoA reductase kinase: measurement of activity by methods that preclude interference by inhibitors of HMG-CoA reductase activity or by mevalonate kinase.
Autor: H J Harwood, Jr, a další
Vydáno: (1982-07-01)

Myeloma cells can promote osteoclastic activity rather than osteoclast recruitment in vitro; Evidence from the 5T2MM murine model of myeloma
Autor: Mueller, G, a další
Vydáno: (2004)

5T2MM murine myeloma cells and CD138+ve human myeloma cells promote osteoclastic activity rather than osteoclast formation in vitro
Autor: Mueller, G, a další
Vydáno: (2004)

Bisphosphonates--mechanisms of action in multiple myeloma.
Autor: Shipman, C, a další
Vydáno: (2000)

The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma.
Autor: Shipman, C, a další
Vydáno: (2000)

HMG CoA reductase of intestinal mucosa and liver of the rat
Autor: S. Shefer, a další
Vydáno: (1972-05-01)

Osteoprotegerin and the development of myeloma bone disease
Autor: Croucher, P, a další
Vydáno: (2004)

Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression.
Autor: JJ Hwa, a další
Vydáno: (1992-05-01)

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase
Autor: Marc M Schumacher, a další
Vydáno: (2015-03-01)

Bisphosphonates and in vivo models of multiple myeloma - Reply
Autor: Shipman, C, a další
Vydáno: (2001)

QSAR Regression Models for Predicting HMG-CoA Reductase Inhibition
Autor: Robert Ancuceanu, a další
Vydáno: (2024-10-01)

HMG-CoA Reductase Inhibitors from Monascus-Fermented Rice
Autor: Xuemei Li, a další
Vydáno: (2013-01-01)

Eupatilin Alleviates Hyperlipidemia in Mice by Inhibiting HMG-CoA Reductase
Autor: Kyung-Joo Kim, a další
Vydáno: (2023-01-01)

The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation
Autor: Paolo Gelosa, a další
Vydáno: (2007-11-01)

Induction of HMG CoA reductase by the administration of 20,25-diazacholesterol
Autor: R Langdon, a další
Vydáno: (1977-01-01)

MTD–CoMSIA modelling of HMG-CoA reductase inhibitors
Autor: DANIEL M. DUDA-SEIMAN, a další
Vydáno: (2011-01-01)

Measurement of human leukocyte microsomal HMG-CoA reductase activity.
Autor: H J Harwood, Jr, a další
Vydáno: (1984-09-01)

Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma
Autor: Croucher, P, a další
Vydáno: (2001)

Atorvastatin action involves diminished recovery of hepatic HMG-CoA reductase activity
Autor: Gene C. Ness, a další
Vydáno: (1998-01-01)

Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation
Autor: Peter C.W. Lee, a další
Vydáno: (2007-02-01)

Rapid reverse phase-HPLC assay of HMG-CoA reductase activity
Autor: Matteo Mozzicafreddo, a další
Vydáno: (2010-08-01)

Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor
Autor: Sucharita Bose, a další
Vydáno: (2023-04-01)

Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain
Autor: Hongwen Chen, a další
Vydáno: (2022-07-01)

Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in <i>Aspergillus fumigatus</i>?
Autor: Irene Gonzalez-Jimenez, a další
Vydáno: (2021-10-01)

Lepidopteran HMG-CoA reductase is a potential selective target for pest control
Autor: Yuan-mei Li, a další
Vydáno: (2017-01-01)

An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia
Autor: Diana S. Gesto, a další
Vydáno: (2020-08-01)

Effects of HMG-CoA Reductase Inhibitors (Statins) On Bone Mineral Density and Metabolism
Autor: Nehir Samancı, a další
Vydáno: (2004-06-01)

Molecular docking studies of Triphala with catalytic portion of HMG-CoA reductase enzyme
Autor: Prasoborn Rinthong, a další
Vydáno: (2023-04-01)

Influence of simvA glyzin on expression and inhibition of hmg-coa reductase in rats liver
Autor: Yu. I. Ragino, a další
Vydáno: (2015-06-01)

Hesperidin Interaction with HMG-CoA-Reductase Enzyme in Hypercholesterolemia: A Study in Silico
Autor: Annisa Rizqi Dwi Oktaviani, a další
Vydáno: (2021-09-01)

HMG-CoA reductase III. Abstracts. June 4, 1983, San Francisco.
Vydáno: (1983-10-01)