Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo.

Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo.

Apomine, a novel 1,1 bisphosphonate ester, increases the rate of degradation of HMG-CoA reductase, inhibiting the mevalonate pathway and thereby blocking cholesterol biosynthesis. We have investigated whether Apomine can induce myeloma cell apoptosis in vitro and modulate myeloma disease in vivo. Ap...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Edwards, C, Mueller, G, Roelofs, A, Chantry, A, Perry, M, Russell, R, Van Camp, B, Guyon-Gellin, Y, Niesor, E, Bentzen, C, Vanderkerken, K, Croucher, P
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2007

Παρόμοια τεκμήρια

Apomine, an inhibitor of HMG-COA-reductase, does not act by inhibiting protein prenylation in human myeloma cells in vitro
ανά: Roelofs, A, κ.ά.
Έκδοση: (2005)

APOMINE (TM), a novel inhibitor of the meyalonate/isoprenoid pathway, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of the myeloma disease in vivo.
ανά: Croucher, P, κ.ά.
Έκδοση: (2002)

Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
ανά: Roelofs, A, κ.ά.
Έκδοση: (2007)

Novel insights into the anti-tumour mechanism of action of apomine and its synergistic interaction with lovastatin in myeloma cells in vitro
ανά: Roelofs, A, κ.ά.
Έκδοση: (2006)

Bisphosphonates and osteoprotegerin as inhibitors of myeloma bone disease.
ανά: Croucher, P, κ.ά.
Έκδοση: (2003)

Myeloma cells can promote osteoclastic activity rather than osteoclast recruitment in vitro; Evidence from the 5T2MM murine model of myeloma
ανά: Mueller, G, κ.ά.
Έκδοση: (2004)

5T2MM murine myeloma cells and CD138+ve human myeloma cells promote osteoclastic activity rather than osteoclast formation in vitro
ανά: Mueller, G, κ.ά.
Έκδοση: (2004)

HMG CoA reductase inhibitors in the treatment of hypercholesterolaemias.
ανά: Aronson, J, κ.ά.
Έκδοση: (1990)

Pleiotropic effects of the HMG-CoA reductase inhibitors
ανά: Mihos CG, κ.ά.
Έκδοση: (2011-04-01)

Regulation of HMG-CoA reductase activity in plants.
ανά: B A Stermer, κ.ά.
Έκδοση: (1994-07-01)

Activation of HMG-CoA reductase by microsomal phosphatase
ανά: K R Feingold, κ.ά.
Έκδοση: (1983-03-01)

The discovery and development of HMG-CoA reductase inhibitors.
ανά: A Endo
Έκδοση: (1992-11-01)

HMG-CoA reductase kinase: measurement of activity by methods that preclude interference by inhibitors of HMG-CoA reductase activity or by mevalonate kinase.
ανά: H J Harwood, Jr, κ.ά.
Έκδοση: (1982-07-01)

Bisphosphonates--mechanisms of action in multiple myeloma.
ανά: Shipman, C, κ.ά.
Έκδοση: (2000)

The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma.
ανά: Shipman, C, κ.ά.
Έκδοση: (2000)

Osteoprotegerin and the development of myeloma bone disease
ανά: Croucher, P, κ.ά.
Έκδοση: (2004)

HMG CoA reductase of intestinal mucosa and liver of the rat
ανά: S. Shefer, κ.ά.
Έκδοση: (1972-05-01)

HMG-CoA reductase is not the site of the primary defect in phytosterolemia
ανά: G.M.B. Berger, κ.ά.
Έκδοση: (1998-05-01)

Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression.
ανά: JJ Hwa, κ.ά.
Έκδοση: (1992-05-01)

Bisphosphonates and in vivo models of multiple myeloma - Reply
ανά: Shipman, C, κ.ά.
Έκδοση: (2001)

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase
ανά: Marc M Schumacher, κ.ά.
Έκδοση: (2015-03-01)

Stimulatory effect of dietary lipid and cholestyramine on hepatic HMG CoA reductase
ανά: Stanley Goldfarb, κ.ά.
Έκδοση: (1972-11-01)

QSAR Regression Models for Predicting HMG-CoA Reductase Inhibition
ανά: Robert Ancuceanu, κ.ά.
Έκδοση: (2024-10-01)

HMG-CoA Reductase Inhibitors from Monascus-Fermented Rice
ανά: Xuemei Li, κ.ά.
Έκδοση: (2013-01-01)

Eupatilin Alleviates Hyperlipidemia in Mice by Inhibiting HMG-CoA Reductase
ανά: Kyung-Joo Kim, κ.ά.
Έκδοση: (2023-01-01)

The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation
ανά: Paolo Gelosa, κ.ά.
Έκδοση: (2007-11-01)

Induction of HMG CoA reductase by the administration of 20,25-diazacholesterol
ανά: R Langdon, κ.ά.
Έκδοση: (1977-01-01)

MTD–CoMSIA modelling of HMG-CoA reductase inhibitors
ανά: DANIEL M. DUDA-SEIMAN, κ.ά.
Έκδοση: (2011-01-01)

Measurement of human leukocyte microsomal HMG-CoA reductase activity.
ανά: H J Harwood, Jr, κ.ά.
Έκδοση: (1984-09-01)

Positive pleiotropic effects of HMG-CoA reductase inhibitor on vitiligo
ανά: Jobin Jean, κ.ά.
Έκδοση: (2004-05-01)

Diurnal variation of HMG CoA reductase activity in rat intestine
ανά: S. Shefer, κ.ά.
Έκδοση: (1972-09-01)

Chronic Onset Form of Anti-HMG-CoA Reductase Myopathy
ανά: Noel Lorenzo Villalba, κ.ά.
Έκδοση: (2021-06-01)

Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma
ανά: Croucher, P, κ.ά.
Έκδοση: (2001)

Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation
ανά: Peter C.W. Lee, κ.ά.
Έκδοση: (2007-02-01)

Atorvastatin action involves diminished recovery of hepatic HMG-CoA reductase activity
ανά: Gene C. Ness, κ.ά.
Έκδοση: (1998-01-01)

Rapid reverse phase-HPLC assay of HMG-CoA reductase activity
ανά: Matteo Mozzicafreddo, κ.ά.
Έκδοση: (2010-08-01)

Inactivation of rat liver HMG-CoA reductase phosphatases by polycarboxylic acids.
ανά: F G Hegardt, κ.ά.
Έκδοση: (1983-07-01)

Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor
ανά: Sucharita Bose, κ.ά.
Έκδοση: (2023-04-01)

Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain
ανά: Hongwen Chen, κ.ά.
Έκδοση: (2022-07-01)

Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in <i>Aspergillus fumigatus</i>?
ανά: Irene Gonzalez-Jimenez, κ.ά.
Έκδοση: (2021-10-01)