Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP3-evoked changes in sino-atrial node beat rate

Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP3-evoked changes in sino-atrial node beat rate

Atrial arrhythmias, such as atrial fibrillation (AF), are a major mortality risk and a leading cause of stroke. The IP3 signalling pathway has been proposed as an atrial-specific target for AF therapy, and atrial IP3 signalling has been linked to the activation of calcium sensitive adenylyl cyclases...

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Bibliographic Details
Main Authors:	Bose, SJ, Read, MJ, Akerman, E, Capel, RA, Ayagama, T, Russell, A, Terrar, DA, Zaccolo, M, Burton, RAB
Format:	Journal article
Language:	English
Published:	Frontiers Media 2022

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